A shared mechanism of SoxR activation by redox-cycling compounds
Article first published online: 31 JAN 2011
© 2011 Blackwell Publishing Ltd
Volume 79, Issue 5, pages 1119–1122, March 2011
How to Cite
Dietrich, L. E. P. and Kiley, P. J. (2011), A shared mechanism of SoxR activation by redox-cycling compounds. Molecular Microbiology, 79: 1119–1122. doi: 10.1111/j.1365-2958.2011.07552.x
- Issue published online: 21 FEB 2011
- Article first published online: 31 JAN 2011
- Accepted 10 January, 2011.
In this issue of Molecular Microbiology, Gu and Imlay show that a class of compounds known as redox-cycling agents directly activate the transcription factor SoxR of Escherichia coli and cause cellular toxicity independent of the production of the reactive oxygen species superoxide. Despite the fact that redox-cycling agents increase formation of superoxide in E. coli, the results described in this new publication revise the long-held assumption that superoxide is responsible for the activation of SoxR and for all of the major toxic effects of redox-cycling drugs. This study also suggests that the critical function of the SoxRS regulon in E. coli is in protection against redox-cycling agents and not exclusively the defence against superoxide.