Interesting twists on small RNA themes in Pseudomonas aeruginosa
Article first published online: 28 MAR 2011
© Published 2011. This article is a US Government work and is in the public domain in the USA
Volume 80, Issue 4, pages 855–859, May 2011
How to Cite
Sharma, C. M. and Storz, G. (2011), Interesting twists on small RNA themes in Pseudomonas aeruginosa. Molecular Microbiology, 80: 855–859. doi: 10.1111/j.1365-2958.2011.07625.x
- Issue published online: 9 MAY 2011
- Article first published online: 28 MAR 2011
- Accepted manuscript online: 11 MAR 2011 05:51AM EST
- Accepted 2 March, 2011.
While many of the initial studies of regulatory small RNA (sRNA) function focused on Escherichia coli and Salmonella, there is expanding characterization of sRNAs in other bacteria. These studies are revealing unique permutations of the themes found in E. coli and Salmonella. This point is nicely illustrated by the Pseudomonas aeruginosa Hfq-binding RNA, PhrS, which activates the synthesis of the key quorum sensing transcription regulator PqsR as described by Sonnleitner et al. in the current issue of Molecular Microbiology. The PhrS RNA combines features of several previously characterized sRNAs; its expression is induced by low oxygen, it encodes a small protein, and it modulates the expression of a quorum sensing regulator by preventing the formation of an inhibitory secondary structure. However, in contrast to other base pairing sRNAs that activate translation, PhrS does not act directly on pqsR but rather increases the translation of a small upstream open reading frame (uof) whose translation is coupled to pqsR.