Protein transport across the cell wall of monoderm Gram-positive bacteria

Authors

  • Brian M. Forster,

    1. Department of Microbiology and Immunology, Cornell University, Ithaca, NY 14853, USA.
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    • Present address: College of Arts & Sciences, St. Joseph's University, Philadelphia, PA 19131, USA.

  • Hélène Marquis

    Corresponding author
    1. Department of Microbiology and Immunology, Cornell University, Ithaca, NY 14853, USA.
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Summary

In monoderm (single-membrane) Gram-positive bacteria, the majority of secreted proteins are first translocated across the cytoplasmic membrane into the inner wall zone. For a subset of these proteins, final destination is within the cell envelope as either membrane-anchored or cell wall-anchored proteins, whereas another subset of proteins is destined to be transported across the cell wall into the extracellular milieu. Although the cell wall is a porous structure, there is evidence that, for some proteins, transport is a regulated process. This review aims at describing what is known about the mechanisms that regulate the transport of proteins across the cell wall of monoderm Gram-positive bacteria.

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