Present address: College of Arts & Sciences, St. Joseph's University, Philadelphia, PA 19131, USA.
Protein transport across the cell wall of monoderm Gram-positive bacteria
Article first published online: 4 APR 2012
© 2012 Blackwell Publishing Ltd
Volume 84, Issue 3, pages 405–413, May 2012
How to Cite
Forster, B. M. and Marquis, H. (2012), Protein transport across the cell wall of monoderm Gram-positive bacteria. Molecular Microbiology, 84: 405–413. doi: 10.1111/j.1365-2958.2012.08040.x
- Issue published online: 20 APR 2012
- Article first published online: 4 APR 2012
- Accepted 13 March, 2012.
In monoderm (single-membrane) Gram-positive bacteria, the majority of secreted proteins are first translocated across the cytoplasmic membrane into the inner wall zone. For a subset of these proteins, final destination is within the cell envelope as either membrane-anchored or cell wall-anchored proteins, whereas another subset of proteins is destined to be transported across the cell wall into the extracellular milieu. Although the cell wall is a porous structure, there is evidence that, for some proteins, transport is a regulated process. This review aims at describing what is known about the mechanisms that regulate the transport of proteins across the cell wall of monoderm Gram-positive bacteria.