Intralipid-induced gastric relaxation is mediated via NO
Version of Record online: 9 NOV 2010
1995 Blackwell Science Ltd
Neurogastroenterology & Motility
Volume 7, Issue 3, pages 151–155, September 1995
How to Cite
MEULEMANS, A. and SCHUURKES, J. (1995), Intralipid-induced gastric relaxation is mediated via NO. Neurogastroenterology & Motility, 7: 151–155. doi: 10.1111/j.1365-2982.1995.tb00220.x
- Issue online: 9 NOV 2010
- Version of Record online: 9 NOV 2010
- Received: 14 December 1994, Accepted for publication:2 March 1995
In vitro, nitric oxide (NO) has been shown to be the neurotransmitter responsible for gastric relaxation. In vivo gastric relaxations can be controlled via reflex pathways originating in the duodenum. The aim of this study was to determine whether NO was involved in gastric relaxation in vivo in conscious dogs induced by intraduodenal administration of intralipid. Gastric tone was monitored with a flaccid bag introduced into the stomach via a gastric cannula and connected to a barostat. Intralipid administration into the duodenum caused a gastric relaxation (420 ± 11 ml, n = 6) sensitive to inhibition by nitro-L-arginine (L-NNA) (5 mg kg−1 i.v.). This inhibitory effect of L-NNA was reversed by L-arginine (100 mg kg−1 i.v.).
In conclusion: intraduodenal administration of intralipid induces a gastric relaxation via a NO-dependent mechanism.