• 1
    Galligan JJ, Bertrand PP. ATP mediates fast synaptic potentials in enteric neurons. J Neurosci 1994; 14: 756371.
  • 2
    Galligan JJ, LePard KJ, Schneider DA, Zhou X. Multiple mechanisms of fast excitatory synaptic transmission in the enteric nervous system. J Auton Nerv Sys 2000; 81: 2000.
  • 3
    LePard KJ, Messori E, Galligan JJ. Purinergic fast excitatory postsynaptic potentials in myenteric neurons of guinea pig: distribution and pharmacology. Gastroenterology 1997; 113: 152234.
  • 4
    Zhou X, Galligan JJ. Synaptic activation and properties of 5-HT3 receptors in myenteric neurons of guinea pig intestine. J Pharmacol Exp Ther 1999; 290: 80310.
  • 5
    LePard KJ, Galligan JJ. Analysis of fast synaptic pathways in myenteric plexus of the guinea pig ileum. Am J Physiol 1997; 276: G52938.
  • 6
    Johnson PJ, Shum OR, Thornton PD, Bornstein JC. Evidence that inhibitory motor neurons of the guinea pig small intestine exhibit fast excitatory postsynaptic potentials mediated via P2X receptors. Neurosci Lett 1999; 266: 16972.
  • 7
    Spencer NJ, Walsh M, Smith TK. Purinergic and cholinergic neuro-neuronal transmission underlying reflexes activated by mucosal stimulation in the isolated guinea-pig ileum. J Physiology 2000; 522: 32131.
  • 8
    Monro RL, Bertrand PP, Bornstein JC. ATP and 5-HT are the principal neurotransmitters in the descending excitatory reflex pathway of the guinea-pig ileum. Neurogastroenterol Motil 2002; 14: 25564.
  • 9
    Bian X, Bertrand PP, Bornstein JC. Descending inhibitory reflexes involve P2X receptor-mediated transmission from interneurons to motor neurons in guinea-pig ileum. J Physiol 2000; 528: 55160.
  • 10
    Brookes SJ, Meedeniya AC, Jobling P, Costa M. Orally projecting interneurones in the guinea-pig small intestine. J Physiol 1997; 505: 47391.
  • 11
    Galligan JJ, North RA. Opioid, 5-HT1A and α2 receptors localized to subsets of guinea pig myenteric neurons. J Auton Nerv Syst 1991; 32: 112.
  • 12
    North RA, Henderson G, Katayama Y, Johnson SM. Electrophysiological evidence for presynaptic inhibition of acetylcholine release by 5-hydroxytryptamine in the enteric nervous system. Neuroscience 1980; 5: 58186.
  • 13
    Galligan JJ, Surprenant A, Tonini M, North RA. Differential localization of 5-HT1 receptors on myenteric and submucosal neurons. Am J Physiol 1988; 255: G60311.
  • 14
    Pan H, Galligan JJ. 5-HT1A and 5-HT4 receptors mediate inhibition and facilitation of fast synaptic transmission in enteric neurons. Am J Physiol 1994; 266: G23038.
  • 15
    Stebbing M, Johnson PJ, Vremec MA, Bornstein JC. Role of alpha(2)-adrenoceptors in the sympathetic inhibition of motility reflexes of guinea-pig ileum. J Physiol 2001; 534: 46578.
  • 16
    Rydelek-Fitzgerald L, Teitler M, Fletcher PW, Ismaiel AM, Glennon RA. NAN190: agonist and antagonist interactions with brain 5-HT1A receptors. Brain Res 1990; 532: 1916.
  • 17
    Wardle KA, Ellis ES, Baxter GS, Kennett GA, Gaster LM, Sanger GJ. The effects of SB 204070, a highly potent and selective 5-HT4 receptor antagonist, on guinea-pig distal colon. Br J Pharmacol 1994; 112: 78994.
  • 18
    Kirchgessner AL, Liu M-TI, Howard MJ, Gershon MD. Detection of the 5-HT1A receptor and 5-HT1A receptor mRNA in the rat bowel and pancreas: comparison with 5-HT1P receptors. J Comp Neurol 1993; 327: 23350.
  • 19
    Kilbinger H, Pfeuffer-Friederich I. Two types of receptors for 5-hydroxytryptamine on the cholinergic nerces of the guinea-pig myenteric plexus. Br J Pharmacol 1985; 85: 52939.
  • 20
    Galligan JJ. Differential inhibition of cholinergic and noncholinergic neurogenic contractions by 5-hydroxytryptamine1A receptor agonists in guinea pig ileum. J Pharmacol Exp Ther 1992; 260: 30612.
  • 21
    Broad RM, McDonald TJ, Cook MA. Adenosine and 5-HT inhibit substance P release from nerve endings in myenteric ganglia by distinct mechanisms. Am J Physiol 1993; 264: G45461.
  • 22
    North RA, Surprenant A. m-opioid receptors and α2-adrenoceptors coexist on myenteric but not on submucous neurones. Neuroscience 1985; 216: 42530.
  • 23
    Shen K-Z, Surprenant A. Mechanisms underlying presynaptic inhibition through α2- adrenoceptors in guinea-pig submucosal neurones. J Physiol 1990; 431: 60928.
  • 24
    Surprenant A, Shen K-Z, North RA, Tatsumi H. Inhibition of calcium currents by noradrenaline, somatostatin and opioids in guinea-pig submucosal neurones. J Physiol 1990; 431: 585608.
  • 25
    Tatsumi H, Costa M, North RA, Schimerlik M. Potassium conductance increased by noradrenaline, opioids, somatostatin, and G-proteins: whole-cell recording from guinea pig submucous neurons. J Neurosci 1990; 10: 167582.
  • 26
    Zhou X, Galligan JJ. Inhibition of calcium currents in cultured myenteric neurons by 5-hydroxytryptamine. Soc Neurosci Abs 1998; 24: 1081.
  • 27
    Buchheit K-H, Buhl T. Prokinetic benzamides stimulate activity in the isolated guinea pig ileum by activation of 5-HT4 receptors. Eur J Pharmacol 1991; 205: 2038.
  • 28
    Schuurkes JAJ, Van Nueten JM, Van Daele PGH, Reyntjens AJ, Janssen PAJ. Motor-stimulating properties of cisapride on isolated gastrointestinal preparations of the guinea pig. J Pharmacol Exp Ther 1985; 234: 77583.
  • 29
    Sanger GJ. Increased gut cholinergic activity and antagonism of 5-hydroxytryptamine M-receptors by BRL 24924: potential clinical importance of BRL 24924. Br J Pharmacol 1987; 91: 7787.
  • 30
    Craig DA, Clarke DE. Pharmacological characterization of neuronal receptor for 5-hydroxytryptamine in guinea-pig ileum with properties similar to the 5-hydroxytryptamine4 receptor. J Pharmacol Exp Ther 1990; 252: 137886.
  • 31
    Wardle KA, Sanger GJ. The guinea-pig distal colon – a sensitive preparation for the investigation of 5-HT4 receptor-mediated contractions. J Pharmacol 110: 15939.
  • 32
    Kilbinger H, Wolf D. Effects of 5-HT4 receptor stimulation on basal and electrically evoked release of acetylcholine from guinea-pig myenteric plexus. Naunyn-Schmiedeberg's Arch Pharmacol 1992; 345: 2705.
  • 33
    Kilbinger H, Gebauer A, Haas J, Ladinsky H, Rizzi CA. Benzimidazolones and renzapride facilitate acetylcholine release from guinea-pig myenteric plexus via 5-HT4 receptors. Naunyn-Schmiedeberg's Arch Pharmacol 1995; 351: 22936.
  • 34
    Tonini M, Galligan JJ, North RA. Effects of cisapride on cholinergic neurotransmission and propulsive motility in the guinea pig ileum. Gastroenterology 1989; 96: 125764.
  • 35
    Bockaert J, Sebben M, Dumuis A. Pharmacological characterization of 5-hydroxytryptamine4 (5-HT4) receptors positively coupled to adenylate cyclase in adult guinea pig hippocampal membrane: effect of substituted benzamide derivatives. Mol Pharmacol 1990; 37: 40811.
  • 36
    Blondel O, Vandecasteele G, Gastineau M et al. Molecular and functional characterization of a 5-HT4 receptor clone from human atrium. FEBS Lett 1997; 412: 46574.
  • 37
    Ansanay H, Sebben M, Bockaert JA, Dumuis A. Characterization of homologous 5- hydroxytryptamine4 receptor desensitization in colliculi neurons. Mol Pharmacol 1992; 42: 80816.
  • 38
    Dumuis A, Sebben M, Bockaert J. The gastrointestinal prokinetic benzamide derivatives are the agonists at the non-classical 5-HT receptor (5-HT4) positively coupled to adenylate cyclase in neurons. Naunyn-Schmiedeberg's Arch Pharmacol 1989; 340: 40310.
  • 39
    Dumuis A, Sebben M, Monferini E et al. Azabicycloalkyl benzimidazolone derivatives as a novel class of potent agonists at the 5-HT4 receptor positively coupled to adenylate cyclase in the brain. Naunyn-Schmiedeberg's Arch Pharmacol 1991; 343: 24551.
  • 40
    Turconi M, Schiantarelli P, Borsini F, Rizzi CA, Ladinsky H, Donetti A. Azabicylcoalkyl benzimidazolones: interaction with serotonergic 5-HT3 and 5-HT4 receptors and potential therapeutic implications. Drugs of the Future 1991; 16: 101126.
  • 41
    Blondel O, Gastineau M, Dahmoune Y, Langlois M, Fischmeister R. Cloning, expression, and pharmacology of four human 5-hydroxytryptamine4 receptor isoforms produced by alternative splicing in the carboxyl terminus. J Neurochem 1998; 70: 225261.
  • 42
    Gerald C, Adham N, Kao H-T et al. The 5-HT4 receptor: molecular cloning and pharmacological characterization of two splice variants. EMBO J 1995; 14: 2315.
  • 43
    Blondel O, Gastineau M, Dahmoune Y, Langlois M, Fischmeister R. Cloning, expression and pharmacology of four human 5-hydroxytryptamin 4 receptor isoforms produced by alternative splicing in the carboxy terminus. J Neurochem 1998; 70: 225261.
  • 44
    Briejer MR, Bosmans JP, Van Daele P et al. The in vitro pharmacological profile of prucalopride, a novel enterokinetic compound. Eur J Pharmacol 2001; 423: 7183.