Comparison of gastric volumes in response to isocaloric liquid and mixed meals in humans
Article first published online: 22 JUL 2004
Neurogastroenterology & Motility
Volume 16, Issue 5, pages 567–573, October 2004
How to Cite
De Schepper, H., Camilleri, M., Cremonini, F., Foxx-Orenstein, A. and Burton, D. (2004), Comparison of gastric volumes in response to isocaloric liquid and mixed meals in humans. Neurogastroenterology & Motility, 16: 567–573. doi: 10.1111/j.1365-2982.2004.00533.x
- Issue published online: 22 JUL 2004
- Article first published online: 22 JUL 2004
- Received: 6 January 2004 Accepted for publication: 2 March 2004
- single protein emission computed tomography (SPECT);
- stomach response to meals;
- gastric volume
Aims: To compare gastric volume responses to ingestion of isocaloric liquid or mixed (solid–liquid) meals and document the intra- and interindividual reproducibility of gastric volume measurement using single photon emission computed tomography (SPECT) imaging after i.v. 99mTc-pertechnetate.
Methods: Eight healthy volunteers performed two studies at least 9 months apart. Gastric volumes were measured after a 317 kcal liquid nutrient meal. Within 2 weeks of the second liquid meal study, participants performed a third study, ingesting an isocaloric mixed meal. The order of the mixed and second liquid meals was randomized; Bland–Altman plot displayed data on repeated studies with liquid meal and paired t-test compared gastric volumes after mixed or liquid isocaloric meals.
Results: Fasting and postprandial gastric volumes associated with the two liquid meals were not significantly different; inter- and intra-individual coefficients of variation were 13 and 13.8%. In response to the mixed meal, there was a lower absolute postprandial volume and lower change in gastric volume over fasting volume compared with the response to the liquid meal (P = 0.0001).
Conclusion: The SPECT measurement of gastric volumes in response to a nutrient liquid meal is reproducible. The magnitude of the volume response is greater after the liquid meal compared with the isocaloric mixed meal.