Postinfectious irritable bowel syndrome may occur after non-gastrointestinal and intestinal infection

Authors


Dr Mark Welfare, University of Newcastle Faculty of Medicine, North Tyneside General Hospital, Rake Lane, North Shields NE29 8NH, UK.
Tel/fax: 0191 293 2574; e-mail: doctormarkw@aol.com

Abstract

Abstract  Postinfectious functional gastrointestinal disorders (FGIDs) may not be specific to gastroenteritis. This pilot study aimed to ascertain the 3- and 6-month incidence of functional gut disorders in people with non-gastrointestinal (GI) infection, gastroenteritis and healthy controls. This was a prospective study of three cohorts recruited from hospital (non-GI infections) and the community (others). FGIDs were diagnosed using self-completed Rome II modular questionnaires administered at baseline, 3 and 6 months. Thirty-six subjects with non-GI infection, 219 healthy subjects and 108 with bacterial gastroenteritis participated. No difference in incidence of FGID was detected between the GI and non-GI infection cohorts. Any FGID was more frequent in people who had a non-GI infection than in controls at both 3 [odds ratio: 4.34 (95% CI: 3.60–16.45)] and 6 months [4.76 (4.42–27.92)]. Irritable bowel syndrome (IBS) alone was more frequent in people with non-GI infections than in controls at 3 months (6.12 [1.30–29.12]) but did not quite reach statistical significance at 6 months (4.58 [0.79–26.46]). Our findings were unexpected. Postinfectious FGIDs may be related to non-GI and GI infection, although not all potential biases were controlled in study design. Further studies need to explore these preliminary findings and, if confirmed, the underlying mechanisms.

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