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CD4+CD25+ regulatory T cells in irritable bowel syndrome patients
Article first published online: 13 DEC 2006
DOI: 10.1111/j.1365-2982.2006.00878.x
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How to Cite
Holmén, N., Isaksson, S., Simrén, M., Sjövall, H. and öhman, L. (2007), CD4+CD25+ regulatory T cells in irritable bowel syndrome patients. Neurogastroenterology & Motility, 19: 119–125. doi: 10.1111/j.1365-2982.2006.00878.x
Publication History
- Issue published online: 13 DEC 2006
- Article first published online: 13 DEC 2006
- Received: 1 February 2006 Accepted for publication: 16 September 2006
References
- 1, , et al. Irritable bowel syndrome and dyspepsia in the general population: overlap and lack of stability over time. Gastroenterology 1995; 109: 671–80.
- 2
- 3, , et al. Dysmotility of the small intestine in irritable bowel syndrome. Gut 1988; 29: 1236–43.
- 4, , et al. Abnormal propagation pattern of duodenal pressure waves in the irritable bowel syndrome (IBS) [correction of (IBD)]. Dig Dis Sci 2000; 45: 2151–61.
- 5, , et al. Altered rectal perception is a biological marker of patients with irritable bowel syndrome. Gastroenterology 1995; 109: 40–52.
- 6, , et al. Rectal hypersensitivity in the irritable bowel syndrome. Int J Colorectal Dis 1997; 12: 29–32.
- 7, , . Abnormal colonic fermentation in irritable bowel syndrome. Lancet 1998; 352: 1187–9.
- 8, , et al. Altered visceral perceptual and neuroendocrine response in patients with irritable bowel syndrome during mental stress. Gut 2004; 53: 1102–8.
- 9, , . An exaggerated sensory component of the gastrocolonic response in patients with irritable bowel syndrome. Gut 2001; 48: 20–7.
- 10, , et al. Inflammation as a cause of functional bowel disorders. Scand J Gastroenterol 2005; 40: 1140–8.
- 11, , et al. Full-thickness biopsy of the jejunum reveals inflammation and enteric neuropathy in irritable bowel syndrome. Gastroenterology 2002; 123: 1972–9.
- 12, , et al. Activation of the mucosal immune system in irritable bowel syndrome. Gastroenterology 2002; 122: 1778–83.
- 13, , et al. A role for inflammation in irritable bowel syndrome? Gut 2002; 51 (Suppl. 1): i41–4.
- 14, , et al. Increased rectal mucosal enteroendocrine cells, T lymphocytes, and increased gut permeability following acute Campylobacter enteritis and in post-dysenteric irritable bowel syndrome. Gut 2000; 47: 804–11.
- 15, , et al. A controlled study of colonic immune activity and beta7+ blood T lymphocytes in patients with irritable bowel syndrome. Clin Gastroenterol Hepatol 2005; 3: 980–6.
- 16, , et al. Interleukin 10 genotypes in irritable bowel syndrome: evidence for an inflammatory component? Gut 2003; 52: 91–3.
- 17, , et al. Increased rectal mucosal expression of interleukin 1beta in recently acquired post-infectious irritable bowel syndrome. Gut 2003; 52: 523–6.
- 18, , et al. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol 1995; 155: 1151–64.
- 19, , et al. CD4+CD25high regulatory cells in human peripheral blood. J Immunol 2001; 167: 1245–53.
- 20. Naturally arising CD4+ regulatory T cells for immunologic self-tolerance and negative control of immune responses. Annu Rev Immunol 2004; 22: 531–62.
- 21, , et al. Functional CD4+CD25high regulatory T cells are enriched in the colonic mucosa of patients with active ulcerative colitis and increase with disease activity. Inflamm Bowel Dis 2006; 12: 447–56.
- 22, , et al. CD4+CD25bright T cells in human intestinal lamina propria as regulatory cells. J Immunol 2004; 173: 3119–30.
- 23, , et al. Defective suppressor function in CD4(+)CD25(+) T-cells from patients with type 1 diabetes. Diabetes 2005; 54: 92–9.
- 24, , et al. Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis. J Exp Med 2004; 199: 971–9.
- 25, , et al. Mucosal FOXP3-expressing CD4+ CD25high regulatory T cells in Helicobacter pylori-infected patients. Infect Immun 2005; 73: 523–31.
- 26, , . Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation. J Exp Med 2000; 192: 295–302.
- 27, , . Cutting edge: cure of colitis by CD4+CD25+ regulatory T cells. J Immunol 2003; 170: 3939–43.
- 28, , . Cutting edge: CD4+CD25+ regulatory T cells impaired for intestinal homing can prevent colitis. J Immunol 2005; 174: 7487–91.
- 29. A case for an immunological basis for irritable bowel syndrome. Gastroenterology 2002; 122: 2078–9.
- 30. Collagenous, microscopic and lymphocytic colitis. An evolving concept. Virchows Arch 1994; 424: 573–9.
- 31, , . CD4+CD25+-regulatory T cells from mouse to man. Scand J Immunol 2005; 62: 1–15.
- 32, , et al. Peripheral and intestinal regulatory CD4+ CD25(high) T cells in inflammatory bowel disease. Gastroenterology 2005; 128: 1868–78.
- 33, , et al. CD4+ CD25+ T cells with the phenotypic and functional characteristics of regulatory T cells are enriched in the synovial fluid of patients with rheumatoid arthritis. Clin Exp Immunol 2005; 140: 360–7.
- 34, , et al. CD25brightCD4+ regulatory T cells are enriched in inflamed joints of patients with chronic rheumatic disease. Arthritis Res Ther 2004; 6: R335–46.
- 35, , et al. Functional assay for human CD4+CD25+ Treg cells reveals an age-dependent loss of suppressive activity. J Neurosci Res 2003; 74: 296–308.
- 36, , et al. CD4+CD25high regulatory T cells are not impaired in patients with primary Sjogren's syndrome. J Autoimmun 2005; 24: 235–42.

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