• 1
    Ritchie J. Pain from distension of the pelvic colon by inflating a balloon in the irritable bowel syndrome. Gut 1973; 6: 105112.
  • 2
    Whitehead WE, Holtkotter B, Enck P et al. Tolerance for rectosigmoid distention in irritable bowel syndrome. Gastroenterology 1990; 98: 118792.
  • 3
    Trimble KC, Farouk R, Pryde A, Douglas S, Heading RC. Heightened visceral sensation in functional gastrointestinal disease is not site-specific. Evidence for a generalized disorder of gut sensitivity. Dig Dis Sci 1995; 40: 160713.
  • 4
    Kellow JE, Eckersley GM, Jones MP. Enhanced perception of physiological intestinal motility in the irritable bowel syndrome. Gastroenterology 1991; 101: 16217.
  • 5
    Camilleri M. Functional bowel disease: roles of sensation and motility. Schweiz Med Wochenschr 2000; 130: 177281.
  • 6
    Sarna, S. Enteric descending and afferent neural signaling stimulated by giant migrating contractions: essential contributing factors to visceral pain. Am J Physiol (in press).
  • 7
    Lembo T, Munakat J, Mertz H et al. Evidence for the hypersensitivity of lumbar splanchnic afferents in irritable bowel syndrome. Gastroenterology 1994; 107: 168696.
  • 8
    Mertz H, Naliboff B, Munakata J, Niazi N, Mayer E. Altered rectal perception is a biological marker of patients with irritable bowel syndrome. Gastroenterology 1995; 109: 4052.
  • 9
    Plourde V, Boivin M, Poitras P, Devroede G, Giguere A. The visceral hypersensitivity and abnormal referral pain patters in patients with irritable bowel syndrome: predictive value of clinical factors. Gastroenterology 1997; 112: A807.
  • 10
    Silverman DHS, Munakata J, Ennes H, Mandelkern MA, Hoh CK, Mayer E. Regional cerebral activity in normal and pathological perception of visceral pain. Gastroenterology 1997; 112: 6472.
  • 11
    Aziz Q, Andersson JLR, Valind S et al. Identification of human brain loci processing esophageal sensation using positron emission tomography. Gastroenterology 1997; 113: 509.
  • 12
    Chang L. Brain responses to visceral and somatic stimuli in irritable bowel syndrome: a central nervous system disorder? Gastroenterol Clin North Am 2005; 34: 2719.
  • 13
    Lawal A, Kern M, Sidhu H, Hofmann C, Shaker R. Novel evidence for hypersensitivity of visceral sensory neural circuitry in irritable bowel syndrome patients. Gastroenterology 2006; 130: 2633.
  • 14
    Cook IJ, Van Eeden A, Collins SM. Patients with the irritable bowel syndrome have greater pain tolerance than normal subjects. Gastroenterology 1987; 93: 72733.
  • 15
    Verne GN, Robinson ME, Price DD. Hypersensitivity to visceral and cutaneous pain in the irritable bowel syndrome. Pain 2001; 93: 714.
  • 16
    Chaudhary NA, Truelove SC. The irritable colon syndrome. A study of the clinical features, predosposing causes and prognosis in 130 cases. Q J Med 1962; 616: 30722.
  • 17
    Ness TJ, Metcalf AM, Gebhart GF. A psychophysiological study in humans using phasic colonic distention as a noxious visceral stimulus. Pain 1990; 43: 37786.
  • 18
    Mayer, EA. Spinal and supraspinal modulation of visceral sensation. Gut 2000; 47: 6972.
  • 19
    Langlois A, Pascaud X, Junien JL, Dahl SG, Riviere PJ. Response heterogeneity of 5-HT3 receptor antagonists in a rat visceral hypersensitivity model. Eur J Pharmacol 1996; 318: 1414.
  • 20
    Plourde V, St-Pierre S, Quirion R. Calcitonin gene-related peptide in viscerosensitive response to colorectal distension in rats. Am J Physiol 1997; 273: G1916.
  • 21
    Greenwood-Van Meerveld B, Venkova K, Hicks G, Dennis E, Crowell MD. Activation of peripheral 5-HT receptors attenuates colonic sensitivity to intraluminal distension. Neurogastroenterol Motil 2006; 18: 7686.
  • 22
    Habler H-J, Janig W, Koltzenburg M. A novel type of unmyelinated chemosensitive nociceptor in the acutely inflammed urinary bladder. Agents Actions 1988; 25: 21921.
  • 23
    Habler H-J, Janig W, Koltzenburg M. Activation of unmyelinated afferent fibres by mechanical stimuli and inflammation in the urinary bladder in the cat. J Physiol (Lond) 1990; 425: 54562.
  • 24
    Jaenig W, Koltzenburg M. On the function of spinal primary afferent fibres supplying the colon and urinary bladder. J Auton Nerv Syst 1990; 30: 58996.
  • 25
    Jaenig W, Koltzenburg M. Receptive properties of sacral primary afferent neurons supplying the colon. J Neurophysiol 1991; 65: 106777.
  • 26
    Cervero F. Mechanisms of acute visceral pain. Br Med Bull 1991; 47: 54960.
  • 27
    Cervero F. Visceral pain: mechanisms of peripheral and central sensitization. Ann Med 1995; 27: 2359.
  • 28
    Oku R, Satoh M, Takagi H. Release of substance P from spinal horn is enhanced in polyarthritic rats. Neurosci Lett 1987; 74: 3159.
  • 29
    Nanayama T, Kuraishi Y, Ohno H, Satoh M. Capsaicin-induced release of calcitonin gene-related peptide from dorsal horn slices is enhanced in adjuvant arthritic rats. Neurosci Res 1989; 6: 56972.
  • 30
    Garry MG, Hargreaves KM. Enhanced release of immunoreactive CGRP and substance P from spinal horn slices occurs during carrageenan inflammation. Brain Res 1992; 582: 13942.
  • 31
    Dubner R, Ruda MA. Activity-dependent neuronal plasticity following tissue injury and inflammation. Trends Neurosci 1992; 15: 96103.
  • 32
    O'Hara JR, Ho W, Linden DR, Mawe GM, Sharkey KA. Enteroendocrine cells and 5-HT availability are altered in mucosa of guinea pigs with TNBS ileitis. Am J Physiol Gastrointest Liver Physiol 2004; 287: G9981007.
  • 33
    O'Hara JR, Lomax AE, Mawe GM, Sharkey KA. Ileitis alters neuronal and enteroendocrine signalling in guinea-pig distal colon. Gut 2006; (in press).
  • 34
    Mawe GM, Branchek TA, Gershon MD. Peripheral neural serotonin receptors: identification and characterization with specific antagonists and agonists. Proc Natl Acad Sci U S A 1986; 83: 9799803.
  • 35
    Pan H, Galligan JJ. 5-HT1A and 5-HT4 receptors mediate inhibition and facilitation of fast synaptic transmission in enteric neurons. Am J Physiol 1994; 266: G2308.
  • 36
    Cooke HJ. Neurotransmitters in neuronal reflexes regulating intestinal secretion. Ann N Y Acad Sci 2000; 915: 7780.
  • 37
    Prins NH, Akkermans LM, Lefebvre RA, Schuurkes JA. 5-HT(4) receptors on cholinergic nerves involved in contractility of canine and human large intestine longitudinal muscle. Br J Pharmacal 2000; 131: 92732.
  • 38
    Mazzia C, Hicks GA, Clerc N. Neuronal location of 5-hydroxytryptamine3 receptor-like immunoreactivity in the rat colon. Neuroscience 2003; 116: 103341.
  • 39
    Hicks GA, Coldwell JR, Schindler M et al. Excitation of rat colonic afferent fibres by 5-HT3 receptors. J Physiol 2002; 544: 8619.
  • 40
    Hillsley K, Grundy D. Sensitivity to 5-hydroxytryptamine in different afferent subpopulations within mesenteric nerves supplying the rat jejunum. J Physiol 1998; 509: 71727.
  • 41
    Raybould HE, Glatzle J, Robin C et al. Expression of 5-HT3 receptors by extrinsic duodenal afferents contribute to intestinal inhibition of gastric emptying. Am J Physiol 2003; 284: G36772.
  • 42
    Craig DA, Clarke DE. Pharmacological characterization of a neuronal receptor for 5-hydroxytryptamine in guinea pig ileum with properties similar to the 5-hydroxytryptamine receptor. J Pharmacol Exp Ther 1990; 252: 137886.
  • 43
    Grider JR, Foxx-Orenstein AE, Jin JG. 5-Hydroxytryptamine4 receptor agonists initiate the peristaltic reflex in human, rat, and guinea pig intestine. Gastroenterology 1998; 115: 37080.
  • 44
    Jin JG, Foxx-Orenstein AE, Grider JR. Propulsion in guinea pig colon induced by 5-hydroxytryptamine (HT) via 5-HT4 and 5-HT3 receptors. J Pharmacol Exp Ther 1999; 288: 937.
  • 45
    Burleigh DE, Borman RA. Short-circuit current responses to 5-hydroxytryptamine in human ileal mucosa are mediated by a 5-HT4 receptor. Eur J Pharmacol 1993; 241: 1258.
  • 46
    Kellum JM, Albuquerque FC, Stoner MC, Harris RP. Stroking human jejunal mucosa induces 5-HT release and Cl- secretion via afferent neurons and 5-HT4 receptors. Am J Physiol 1999; 277: G51520.
  • 47
    Galligan JJ, Pan H, Messori E. Signalling mechanism coupled to 5-hydroxytryptamine4 receptor-mediated facilitation of fast synaptic transmission in the guinea-pig ileum myenteric plexus. Neurogastroenterol Motil 2003; 15: 5239.
  • 48
    LePard KJ, Ren J, Galligan JJ. Presynaptic modulation of cholinergic and non-cholinergic fast synaptic transmission in the myenteric plexus of guinea pig ileum. Neurogastroenterol Motil 2004; 16: 35564.
  • 49
    Leclere PG, Prins NH, Schuurkes JAJ, Lefebvre RA. 5-HT4 receptors located on cholinergic nerves in human colon circular muscle. Neurogastroenterol Motil 2005; 17: 110.
  • 50
    Morteau O, Hachet T, Caussette M, Bueno L. Experimental colitis alters visceromotor response to ccolorectal distention in awake rats. Dig Dis Sci 1994; 39: 123948.
  • 51
    Morteau O, Julia V, Eeckhout C, Bueno L. Influence of 5-HT3 receptor antagonists in visceromotor and nociceptive responses to rectal distention before and during experimental colitis in rats. Fundam Clin Pharmacol 1994; 8: 55362.
  • 52
    Schikowski A, Thewissen M, Mathis C, Ross HG, Enck P. Serotonin type-4 receptors modulate the sensitivity of intramural mechanoreceptive afferents of the cat rectum. Neurogastroenterol Motil 2002; 14: 2217.
  • 53
    Hicks JA, Clayton NM, Gaskin PJ et al. 5-HT4 receptor agonists stimulate small intestinal transit but do not have direct visceral antinociceptive effects in the rat. Gastroenterology 2001; 120: A-6.
  • 54
    Wei JY, Wang YH, Mayer E. The 5-HT4 receptor partial agonist, tegaserod, inhibits the colorectal distension-induced responses of rat inferior splanchnic afferents in vitro. Gastroenterology 2002; 122: A-317.
  • 55
    Sun YN, Luo JY. Effects of tegaserod on Fos, substance P and calcitonin gene-related peptide expression induced by colon inflammation in lumbarsacral spinal cord. World J Gastroenterol 2004; 10: 18303.
  • 56
    Camilleri M. Review article: tegaserod. Aliment Pharmacol Ther 2001; 15: 27789.
  • 57
    Beattie DT, Smith JAM, Marquess D et al. The 5-HT4 receptor agonist, tegaserod, is a potent 5-HT2B receptor antagonist in vitro and in vivo. Br J Pharmacol 2004; 143: 54960.
  • 58
    Holohean AM, Hackman JC. Mechanisms intrinsic to 5-HT2B receptor-induced potentiation of NMDA receptor responses in frog motorneurones. Br J Pharmacol 2004; 143: 35160.