• 1
    Bilgutay AM, Wingrove R, Griffen WO, Bonnabeau RC, Lillehei CW. Gastro-intestinal pacing: a new concept in the treatment of ileus. Ann Surg 1963; 158: 33848.
  • 2
    Kelly KA, La Force RC. Pacing the canine stomach with electric stimulation. Am J Physiol 1972; 222: 58894.
  • 3
    Kelly KA. Differential responses of the canine gastric corpus and antrum to electric stimulation. Am J Physiol 1974; 226: 2304.
  • 4
    Bellahsene BE, Lind CD, Schirmer BD, Updike OL, McCallum RW. Acceleration of gastric emptying with electrical stimulation in a canine model of gastroparesis. Am J Physiol 1992; 262: G82634.
  • 5
    Hocking MP, Vogel SB, Sninsky CA. Human gastric myoelectric activity and gastric emptying following gastric surgery and with pacing. Gastroenterology 1992; 103: 18116.
  • 6
    Lin ZY, McCallum RW, Schirmer BD, Chen JD. Effects of pacing parameters on entrainment of gastric slow waves in patients with gastroparesis. Am J Physiol 1998; 274: G18691.
  • 7
    McCallum RW, Chen JD, Lin Z, Schirmer BD, Williams RD, Ross RA. Gastric pacing improves emptying and symptoms in patients with gastroparesis. Gastroenterology 1998; 114: 45661.
  • 8
    Familoni BO, Abell TL, Nemoto D, Voeller G, Johnson B. Efficacy of electrical stimulation at frequencies higher than basal rate in canine stomach. Dig Dis Sci 1997; 42: 8927.
  • 9
    Familoni BO, Abell TL, Voeller G, Salem A, Gaber O. Electrical stimulation at a frequency higher than basal rate in human stomach. Dig Dis Sci 1997; 42: 88591.
  • 10
    Song G, Hou X, Yang B et al. Efficacy and efficiency of gastric electrical stimulation with short pulses in the treatment of vasopressin-induced emetic responses in dogs. Neurogastroenterol Motil 2006; 18: 38591.
  • 11
    Chen JD, Qian L, Ouyang H, Yin J. Gastric electrical stimulation with short pulses reduces vomiting but not dysrhythmias in dogs. Gastroenterology 2003; 124: 4019.
  • 12
    The GEMS Study Group. Long-term results of gastric stimulation four times higher than the slow wave frequency in patients with drug-refractory gastroparesis (abstract). Gastroenterology 1999; 116: G4131.
  • 13
    Abell TL, Van Cutsem E, Abrahamsson H et al. Gastric electrical stimulation in intractable symptomatic gastroparesis. Digestion 2002; 66: 20412.
  • 14
    Abell T, Lou J, Tabbaa M, Batista O, Malinowski S, Al-Juburi A. Gastric electrical stimulation for gastroparesis improves nutritional parameters at short, intermediate, and long-term follow-up. J Parenter Enteral Nutr 2003; 27: 27781.
  • 15
    Forster J, Sarosiek I, Lin Z et al. Further experience with gastric stimulation to treat drug refractory gastroparesis. Am J Surg 2003; 186: 6905.
  • 16
    Cutts TF, Luo J, Starkebaum W, Rashed H, Abell TL. Is gastric electrical stimulation superior to standard pharmacologic therapy in improving GI symptoms, healthcare resources, and long-term health care benefits? Neurogastroenterol Motil 2005; 17: 3543.
  • 17
    Lin Z, McElhinney C, Sarosiek I, Forster J, McCallum R. Chronic gastric electrical stimulation for gastroparesis reduces the use of prokinetic and/or antiemetic medications and the need for hospitalizations. Dig Dis Sci 2005; 50: 132834.
  • 18
    Lin Z, Sarosiek I, Forster J, McCallum RW. Symptom responses, long-term outcomes and adverse events beyond 3 years of high-frequency gastric electrical stimulation for gastroparesis. Neurogastroenterol Motil 2006; 18: 1827.
  • 19
    Maranki JL, Lytes V, Meilahn JE et al. Predictive factors for clinical improvement with Enterra gastric electrical stimulation treatment for refractory gastroparesis. Dig Dis Sci 2008; 53: 20728.
  • 20
    Anand C, Al-Juburi A, Familoni B et al. Gastric electrical stimulation is safe and effective: a long-term study in patients with drug-refractory gastroparesis in three regional centers. Digestion 2007; 75: 839.
  • 21
    Abell T, McCallum R, Hocking M et al. Gastric electrical stimulation for medically refractory gastroparesis. Gastroenterology 2003; 125: 4218.
  • 22
    Jones MP. Gastric electrical stimulation for refractory gastroparesis (letter). Gastroenterology 2004; 126: 62930.
  • 23
    Al-Juburi A, Granger S, Barnes J et al. Laparoscopy shortens the length of stay in patients with gastric electrical stimulators. J Soc Laparoendo Surg 2005; 9: 30510.
  • 24
    Raju GS, Forster J, Sarosiek I, Rosenthal SJ, Lin Z, McCallum R. EUS guidance in gastric pacemaker implantation. Gastrointest Endosc 2002; 55: 72830.
  • 25
    McCallum R, Lin Z, Wetzel P, Sarosiek I, Forster J. Clinical response to gastric electrical stimulation in patients with postsurgical gastroparesis. Clin Gastroenterol Hepatol 2005; 3: 4954.
  • 26
    Salameh JR, Schmieg RE, Runnels JM, Abell TL. Refractory gastroparesis after Roux-en-Y gastric bypass: surgical treatment with implantable pacemaker. J Gastrointest Surg 2007; 11: 166972.
  • 27
    Filichia LA, Cendan JC. Small case series of gastric stimulation for the management of transplant-induced gastroparesis. J Surg Res 2008; 148: 903.
  • 28
    Andersson S, Lonroth H, Simren M, Ringstrom G, Elfvin A, Abrahamsson H. Gastric electrical stimulation for intractable vomiting in patients with chronic intestinal pseudoobstruction. Neurogastroenterol Motil 2006; 18: 82330.
  • 29
    Gourcerol G, Leblanc I, Leroi AM, Denis P, Ducrotte P. Gastric electrical stimulation in medically refractory nausea and vomiting. Eur J Gastroenterol Hepatol 2007; 19: 2935.
  • 30
    Islam S, Vick LR, Runnels MJ, Gosche JR, Abell T. Gastric electrical stimulation for children with intractable nausea and gastroparesis. J Ped Surg 2008; 43: 43742.
  • 31
    Van der Voort IR, Becker JC, Dietl KH, Konturek JW, Domschke W, Pohle T. Gastric electrical stimulation results in improved metabolic control in diabetic patients suffering from gastroparesis. Exp Clin Endocrinol Diab 2005; 113: 3842.
  • 32
    Abidi N, Starkebaum WL, Abell TL. An energy algorithm improves symptoms in some patients with gastroparesis and treated with gastric electrical stimulation. Neurogastroenterol Motil 2006; 18: 3348.
  • 33
    Lin Z, Hou Q, Sarosiek I, Forster J, McCallum RW. Association between changes in symptoms and gastric emptying in gastroparetic patients treated with gastric electrical stimulation. Neurogastroenterol Motil 2008; 20: 46470.
  • 34
    Forster J, Damjanov I, Lin Z, Sarosiek I, Wetzel P, McCallum RW. Absence of the interstitial cells of Cajal in patients with gastroparesis and correlation with clinical findings. J Gastrointest Surg 2005; 9: 1028.
  • 35
    Ayinala S, Batista O, Goyal A et al. Temporary gastric electrical stimulation with orally or PEG-placed electrodes in patients with drug refractory gastroparesis. Gastrointest Endosc 2005; 61: 45561.
  • 36
    Curuchi AP, Al-Juburi A, Familoni B et al. Gastric electrical stimulation – a ten year experience (abstract). Gastroenterology 2004; 126: W1284.
  • 37
    Liu J, Qiao X, Micci MA, Pasricha PJ, Chen JD. Improvement of gastric motility with gastric electrical stimulation in STZ-induced diabetic rats. Digestion 2004; 70: 15966.
  • 38
    Bityutskiy LP, Soykan I, McCallum RW. Viral gastroparesis: a subgroup of idiopathic gastroparesis – clinical characteristics and long-term outcomes. Am J Gastroenterol 1997; 92: 15014.
  • 39
    Xing JH, Chen JD. Effects and mechanisms of long-pulse gastric electrical stimulation on canine gastric tone and accommodation. Neurogastroenterol Motil 2006; 18: 13643.
  • 40
    McCallum RW, Dusing RW, Sarosiek I, Cocjin J, Forster J, Lin Z. Mechanisms of high-frequency electrical stimulation of the stomach in gastroparetic patients. Conf Proc Ann Intern Conf IEEE Engin Med Biol Soc 2006; 1: 54003.
  • 41
    Qin C, Chen JD, Zhang J, Foreman RD. Modulatory effects and afferent pathways of gastric electrical stimulation on rat thoracic spinal neurons receiving input from the stomach. Neurosci Res 2007; 57: 2939.
  • 42
    Tang M, Zhang J, Chen JD. Central mechanisms of gastric electrical stimulation involving neurons in the paraventricular nucleus of the hypothalamus in rats. Obesity Surg 2006; 16: 34452.
  • 43
    Chen JD, Xu X, Zhang J et al. Efficiency and efficacy of multi-channel gastric electrical stimulation. Neurogastroenterol Motil 2005; 17: 87882.
  • 44
    Song G, Hou X, Yang B, Liu J, Qian W, Chen JD. Two-channel gastric electrical stimulation accelerates delayed gastric emptying induced by vasopressin. Dig Dis Sci 2005; 50: 6628.
  • 45
    Sarosiek I, Forster J, Roeser K, McCallum R. Effect of multi-point gastric electrical pacing (MGP) and symptoms, gastric emptying and electrical activity in diabetic gastroparesis (abstract). Gastroenterology 2008; 134: 847.
  • 46
    Zhu H, Sallam H, Chen DD, Chen JD. Therapeutic potential of synchronized gastric electrical stimulation for gastroparesis: enhanced gastric motility in dogs. Am J Physiol Regul Integ Comp Physiol 2007; 293: R187581.
  • 47
    Mintchev MP, Sanmiguel CP, Otto SJ, Bowes KL. Microprocessor controlled movement of liquid gastric content using sequential neural electrical stimulation. Gut 1998; 43: 60711.
  • 48
    Jalilian E, Onen D, Neshev E, Mintchev MP. Implantable neural electrical stimulator for external control of gastrointestinal motility. Med Eng Phys 2007; 29: 23852.
  • 49
    Song GQ, Hou X, Yang B, Sun Y, Qian W, Chen JD. A novel method of 2-channel dual-pulse gastric electrical stimulation improves solid gastric emptying in dogs. Surgery 2008; 143: 728.
  • 50
    Elfvin A, Andersson S, Abrahamsson H, Edebo A, Simren M, Lonroth H. Percutaneous implantation of gastric electrodes – a novel technique applied in animals and in patients. Neurogastroenterol Motil 2007; 19: 1039.
  • 51
    Abrahamsson H, Lonroth H, Simren M. Progress in gastric electrical stimulation (letter). Gastrointest Endosc 2008; 67: 120910.
  • 52
    Sallam HS, Chen JD, Pasricha PJ. Feasibility of gastric electrical stimulation by percutaneous endoscopic transgastric electrodes. Gastrointest Endosc 2008; 68: 7549.
  • 53
    D’Argent J. Gastric electrical stimulation as therapy of morbid obesity: preliminary results from the French study. Obesity Surg 2002; 12 (Suppl. 1): 21S5S.
  • 54
    Cigaina V. Gastric pacing as therapy for morbid obesity: preliminary results. Obesity Surg 2002; 12 (Suppl. 1): 12S6S.
  • 55
    Bohdjalian A, Prager G, Aviv R et al. One-year experience with Tantalus: a new surgical approach to treat morbid obesity. Obesity Surg 2006; 16: 62734.
  • 56
    Peles S, Petersen J, Aviv R et al. Enhancement of antral contractions and vagal afferent signaling with synchronized electrical stimulation. Am J Physiol-Gastrointest Liver Physiol 2003; 285: G57785.
  • 57
    Neshev E, Onen D, Jalilian E, Mintchev MP. Pre-pyloric neural electrical stimulation produces cholinergically-mediated reverse peristalsis in the acute canine model of microprocessor-invoked gastric motility for the treatment of obesity. Obesity Surg 2006; 16: 51020.
  • 58
    Yao S, Ke M, Wang Z, Xu D, Zhang Y, Chen JD. Retrograde gastric pacing reduces food intake and delays gastric emptying in humans: a potential therapy for obesity? Dig Dis Sci 2005; 50: 156975.
  • 59
    Cigaina V. Long-term follow-up of gastric stimulation for obesity: the Mestre 8-year experience. Obesity Surg 2004; 14 (Suppl. 1): S1422.
  • 60
    De Luca M, Segato G, Busetto L et al. Progress in implantable gastric stimulation: summary of results of the European multi-center study. Obesity Surg 2004; 14 (Suppl. 1): S339.
  • 61
    Shikora SA. “What are the yanks doing?” The US experience with implantable gastric stimulation (IGS) for the treatment of obesity – update on the ongoing clinical trials. Obesity Surg 2004; 14 (Suppl. 1): S408.
  • 62
    Hoeller E, Aigner F, Margreiter R, Weiss H. Intragastric stimulation is ineffective after failed adjustable gastric banding. Obesity Surg 2006; 16: 11605.
  • 63
    Champion JK, Williams M, Champion S, Gianos J, Carrasquilla C. Implantable gastric stimulation to achieve weight loss in patients with a low body mass index: early clinical trial results. Surg Endo 2006; 20: 4447.
  • 64
    Zhu H, Chen JD. Implantable gastric stimulation inhibits gastric motility via sympathetic pathway in dogs. Obesity Surg 2005; 15: 95100.
  • 65
    Liu J, Hou X, Song G, Cha H, Yang B, Chen JD. Gastric electrical stimulation using endoscopically placed mucosal electrodes reduces food intake in humans. Am J Gastroenterol 2006; 101: 798803.
    Direct Link:
  • 66
    Sun Y, Chen JD. Gastric electrical stimulation inhibits postprandial antral tone partially via nitrergic pathway in conscious dogs. Am J Physiol Regul Integ Comp Physiol 2006; 290: R9048.
  • 67
    Sanmiguel CP, Haddad W, Aviv R et al. The TANTALUS system for obesity: effect on gastric emptying of solids and ghrelin plasma levels. Obesity Surg 2007; 17: 15039.
  • 68
    Lei Y, Xing J, Chen JD. Effects and mechanisms of implantable gastric stimulation on gastric distention in conscious dogs. Obesity Surg 2005; 15: 52833.
  • 69
    Ouyang H, Xing J, Chen JD. Tachygastria induced by gastric electrical stimulation is mediated via alpha- and beta-adrenergic pathway and inhibits antral motility in dogs. Neurogastroenterol Motil 2005; 17: 84653.
  • 70
    Cigaina V, Hirschberg AL. Gastric pacing for morbid obesity: plasma levels of gastrointestinal peptides and leptin. Obesity Res 2003; 11: 145662.
  • 71
    Xing JH, Lei Y, Ancha HR, Harty RF, Chen JD. Effect of acute gastric electrical stimulation on the systemic release of hormones and plasma glucose in dogs. Dig Dis Sci 2007; 52: 495501.
  • 72
    Song GQ, Hou X, Sun Y, Yang B, Qian W, Chen JD. Effects of retrograde gastric electrical stimulation with pulse trains on gastric emptying of solids and plasma hormones in dogs. Am J Surg 2007; 194: 1227.
  • 73
    Sobocki J, Fourtanier G, Estany J, Otal P. Does vagal nerve stimulation affect body composition and metabolism? Experimental study of a new potential technique in bariatric surgery. Surgery 2006; 139: 20916.
  • 74
    Ruffin M, Nicolaidis S. Electrical stimulation of the ventromedial hypothalamus enhances both fat utilization and metabolic rate that preceed and parallel the inhibition of feeding behavior. Brain Res 1999; 846: 239.
  • 75
    Sani S, Jobe K, Smith A, Kordower JH, Bakay RA. Deep brain stimulation for treatment of obesity in rats. J Neurosurg 2007; 107: 80913.
  • 76
    Qin C, Chen JD, Zhang J, Foreman RD. Characterization of T9-T10 spinal neurons with duodenal input and modulation by gastric electrical stimulation in rats. Brain Res 2007; 1152: 7586.
  • 77
    Wang GJ, Yang J, Volkow ND et al. Gastric stimulation in obese subjects activates the hippocampus and other regions involved in brain reward circuitry. Proc Nat Acad Sci USA 2006; 103: 156415.
  • 78
    Tang M, Zhang J, Xu L, Chen JD. Implantable gastric stimulation alters expression of oxytocin- and orexin-containing neurons in the hypothalamus of rats. Obesity Surg 2006; 16: 7629.
  • 79
    Liu S, Tang M, Tao S, Chen JD. Central expressions of ghrelin and cholecystokinin in rats with gastric electrical stimulation. Obesity Surg 2008; 18: 10914.
  • 80
    Jones KL, Russo A, Berry MK, Stevens JE, Wishart JM, Horowitz M. A longitudinal study of gastric emptying and upper gastrointestinal symptoms in patients with diabetes mellitus. Am J Med 2002; 113: 44955.
  • 81
    O’Brien PE, Dixon JB, Laurie C et al. Treatment of mild to moderate obesity with laparoscopic adjustable gastric banding or an intensive medical program: a randomized trial. Ann Intern Med 2006; 144: 62533.