Brain imaging approaches to the study of functional GI disorders: A Rome Working Team Report

Authors

  • E. A. Mayer,

    1. Center for Neurobiology of Stress, Departments of Medicine, Physiology and Psychiatry, Division of Digestive Diseases, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA
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  • Q. Aziz,

    1. Wingate Institute for Neurogastroenterology, Neurogastroenterology Group, School of Medicine and Dentistry, Queen Mary University of London, London, UK
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  • S. Coen,

    1. Wingate Institute for Neurogastroenterology, Neurogastroenterology Group, School of Medicine and Dentistry, Queen Mary University of London, London, UK
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  • M. Kern,

    1. Division of Gastroenterology and Hepatology, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA
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  • J. S. Labus,

    1. Center for Neurobiology of Stress, Departments of Medicine, Physiology and Psychiatry, Division of Digestive Diseases, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA
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  • R. Lane,

    1. Departments of Psychiatry, Psychology and Neuroscience, University of Arizona, Tucson, AZ, USA
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  • B. Kuo,

    1. Gastro Intestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
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  • B. Naliboff,

    1. Center for Neurobiology of Stress, Departments of Medicine, Physiology and Psychiatry, Division of Digestive Diseases, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA
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  • I. Tracey

    1. Oxford Centre for Functional Magnetic Resonance Imaging of the Brain, FMRIB Centre, Oxford University, Department of Clinical Neurology, John Radcliffe Hospital, Oxford, UK
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Emeran A. Mayer, MD, Center for Neurobiology of Stress, GLA VA HC, Bldg. 115/CURE, 11301 Wilshire Blvd., Los Angeles, CA 90073, USA.
Tel: 310-312-9276; fax: 310-794-2864; e-mail: emayer@ucla.edu

Abstract

Abstract Progresses in the understanding of human brain-gut interactions in health and disease have been limited by the lack of non-invasive techniques to study brain activity. The advent of neuroimaging techniques has made it possible not only to study the structure and function of the brain, but also to characterize signaling system underlying brain function. This article gives a brief overview of relevant functional neuroanatomy, and of the most commonly used brain imaging techniques. It summarizes published functional brain imaging studies using acute visceral stimulation of the oesophagus, stomach and colon in healthy control subjects and patients with functional GI disorders, and briefly discusses pertinent findings from these studies. The article concludes with a critical assessment of published studies, and with recommendations for improved study paradigms and analysis strategies.

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