Chronic constipation: overview and challenges


Professor Ian J. Cook, Department of Gastroenterology, St George Hospital, University of NSW, Kogarah, NSW 2217, Australia.
Tel: +61 2 9113 2817; fax: +61 2 9113 3993; e-mail:


Abstract  Despite its high prevalence and cost implications, our understanding of the pathophysiology of constipation remains primitive, and available therapies have limited efficacy. The purpose of this supplement is to address critically the reasons for the current lack of understanding and to propose avenues of future research to address these deficiencies.