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Pathophysiology of colonic causes of chronic constipation


Dr Phil G. Dinning, Department of Gastroenterology, St George Hospital, University of NSW, Kogarah, NSW, 2217, Australia.
Tel: +61 2 935 02817; fax: +61 2 935 03993; e-mail:


Abstract  Colonic sensorimotor dysfunction is recognized as the principal pathophysiological mechanism underpinning chronic constipation. This review addresses current understanding derived from both human and animal studies, with particular reference made to methods of investigation.