• 1
    Lee KT, Rhee PL, Kim J et al. Assessment of autonomic tone over a 24-hour period in patients with irritable bowel syndrome (abstr). Gastroenterology 1997; 112: A773.
  • 2
    Everhart JE, Renault PF. Irritable bowel syndrome in office based practice in the United States. Gastroenterology 1991; 100: 9881005.
  • 3
    Levy RL, Stang P, Von Korff M et al. Longitudinal study of the comparative costs of IBS in an HMO (abstr). Am J Gastroenterol 2000; 95: A2540.
    Direct Link:
  • 4
    Camilleri M. Motor function in irritable bowel syndrome. Can J Gastroenterol 1999; 13(Suppl A): 8A11A.
  • 5
    Harraf F, Schmulson M, Saba L et al. Subtypes of constipation predominant irritable bowel syndrome based on rectal perception. Gut 1998; 43: 38894.
  • 6
    Rao SS, Ozturk R, De Ocampo S et al. Clinical utility of diagnostic tests for constipation in adults: a systemic review. Am J Gastroenterol 2005; 100: 160515.
    Direct Link:
  • 7
    Mertz H, Naliboff B, Mayer EA et al. Symptoms and physiology in severe chronic constipation. Am J Gastroenterol 1999; 94: 1318.
    Direct Link:
  • 8
    Camilleri M, Zinsmeister AR. Towards a relatively inexpensive, noninvasive, accurate test for colonic motility disorders. Gastroenterology 1992; 103: 3642.
  • 9
    Vassallo M, Camilleri M, Phillips SF et al. Transit through the proximal colon influences stool weight in the irritable bowel syndrome. Gastroenterology 1992; 102: 1028.
  • 10
    Flegal KM, Carroll MD, Odgen CL et al. Prevalence and trends in obesity among US adults, 1999-2000. JAMA 2002; 288: 17237.
  • 11
    Delgado-Aros S, Locke GR, Camilleri M et al. Obesity is associated with increased risk of gastrointestinal symptoms: a population-based study. Am J Gastroenterol 2004; 99: 18016.
    Direct Link:
  • 12
    Talley NJ, Howel S, Poulton R. Obesity and chronic gastrointestinal tract symptoms in young adults: a birth cohort study. Am J Gastroenterol 2004; 99: 180714.
    Direct Link:
  • 13
    Talley NJ, Quan C, Jones MP et al. Association of upper and lower gastrointestinal symptoms with body mass index in an Australian cohort. Neurogastroenterol Motil 2004; 16: 4139.
  • 14
    Proano M, Camilleri M, Phillips SF et al. Transit of solids through the human colon: regional quantification in the unprepared bowel. Am J Physiol 1990; 258: G856.
  • 15
    Burton DD, Camilleri M, Mullan BP et al. Colonic transit scintigraphy labeled activated charcoal compared with ion exchange pellets. J Nucl Med 1997; 38: 180710.
  • 16
    Cremonini F, Mullan BP, Camilleri M et al. Performance characteristics of scintigraphic transit measurements for studies of experimental therapies. Aliment Pharmacol Ther 2002; 16: 178190.
  • 17
    Bennett EJ, Evans P, Scott AM et al. Psychological and sex features of delayed gut transit in functional gastrointestinal disorders. Gut 2000; 46: 837.
  • 18
    Bouchoucha M, Devroede G, Dorval E et al. Different segmental transit times in patients with irritable bowel syndrome and “normal” colonic transit time: is there a correlation with symptoms? Tech Coloproctol 2006; 10: 28796.
  • 19
    Sadik R, Stotzer PO, Simren M et al. Gastrointestinal transit abnormalities are frequently detected in patients with unexplained GI symptoms at a tertiary center. Neurogastroenterol Motil 2008; 20: 197205.
  • 20
    Cann PA, Read NW, Brown C et al. Irritable bowel syndrome: relationship of disorders in the transit of a single solid meal to symptom pattern. Gut 1983; 24: 40511.
  • 21
    Stivland T, Camilleri M, O’Brien MD et al. Scintigraphic measurement of regional gut transit in idiopathic constipation. Gastroenterology 1991; 101: 10715.
  • 22
    Debongnie JC, Phillips SF. Capacity of the human colon to absorb fluid. Gastroenterology 1978; 74: 698703.
  • 23
    Thompson WG, Longstreth G, Drossman DA et al. Functional bowel disorders and functional abdominal pain. In: DrossmanDA, CorazziariE, TalleyNJ et al. , eds. Rome II: The Functional Gastrointestinal Disorders. 2nd Ed. McLean, VA: Degnon Associates, 2000: 351432.
  • 24
    Posserud I, Stotzer PO, Bjomsson ES et al. Small intestinal bacterial overgrowth in patients with irritable bowel syndrome. Gut 2007; 56: 8028.
  • 25
    Bulpitt CJ, Palmer AJ, Battersby C et al. Association of symptoms of type II diabetic patients with severity of disease, obesity, and blood pressure. Diabetes Care 1998; 21: 1115.
  • 26
    Delgado-Aros S, Camilleri M, Garcia MA et al. High body mass alters colonic sensory-motor function and transit in humans. Am J Physiol 2008; 295: G3828.
  • 27
    Bertin E, Schneider N, Abdelli N et al. Gastric emptying is accelerated in obese type 2 diabetic patients without autonomic neuropathy. Diabetes Metab 2001; 27: 35764.
  • 28
    Verdich C, Madsen JL, Toubro S et al. Effect of obesity and major weight reduction on gastric emptying. Int J Obes Relat Metab Disord 2000; 24: 899905.
  • 29
    Miettinen TA. Cholesterol production in obesity. Circulation 1971; 44: 84250.
  • 30
    Reuben A, Qureshi Y, Murphy GM et al. Effect of obesity and weight reduction on biliary cholesterol saturation and the response to chenodeoxycholic acid. Eur J Clin Invest 1986; 16: 13342.
  • 31
    Sadik R, Abrahamsson H, Ung KA et al. Accelerated regional bowel transit and overweight shown in idiopathic bile acid malabsorption. Am J Gastroenterol 2004; 99: 7118.
    Direct Link:
  • 32
    Simren M, Mansson A, Langkilde AM et al. Food-related gastrointestinal symptoms in the irritable bowel syndrome. Digestion 2001; 163: 10815.
  • 33
    Camilleri M, McKinzie S, Busciglio I et al. Prospective study of motor, sensory, psychologic, and autonomic functions in patients with irritable bowel syndrome. Clin Gastroenterol Hepatol 2008; 6: 77281.
  • 34
    Choi MG, Camilleri M, O’Brien MD, Kammer PP, Hanson RB. A pilot study of motility and tone of the left colon in patients with diarrhea due to functional disorders and dysautonomia. Am J Gastroenterol 1997; 92: 297302.
  • 35
    Chey WY, Jin HO, Lee MH, Sun SW, Lee KY. Colonic motility abnormality in patients with irritable bowel syndrome exhibiting abdominal pain and diarrhea. Am J Gastroenterol 2001; 96: 1499506.
    Direct Link:
  • 36
    Cook IJ, Furukawa Y, Panagopoulos V, Collins PJ, Dent J. Relationships between spatial patterns of colonic pressure and individual movements of content. Am J Physiol 2000; 278: G32941.
  • 37
    Longstreth GF, Thompson WG, Houghton LA et al. Functional bowel disorders. In: DrossmanDA, CorazziariE, DelvauxM et al. , eds. Rome III: The Functional Gastrointestinal Disorders. 3rd Ed. McLean, VA: Degnon Associates, 2006: 487555.
  • 38
    Mearin F, Balboa A, Badia X et al. Irritable bowel syndrome subtypes according to bowel habit: revisiting the alternating subtype. Eur J Gastroenterol Hepatol 2003; 15: 16572.
  • 39
    Lewis SJ, Heaton KW. Stool form scale as a useful guide to intestinal transit time. Scand J Gastroenterol 1997; 32: 9204.
  • 40
    Mearin F, Baró E, Roset M et al. Clinical pattern over time in irritable bowel syndrome: symptom instability and severity variability. Am J Gastroenterol 2004; 99: 11321.
    Direct Link:
  • 41
    Levy R, Linde JA, Feld KA et al. The association of gastrointestinal symptoms with weight, diet, and exercise in weight-loss program participants. Clin Gastroenterol Hepatol 2005; 3: 9926.
  • 42
    Heaton KW, Radvan J, Cripps H et al. Defecation frequency and timing, and stool form in the general population: a prospective study. Gut 1992; 33: 81824.
  • 43
    Viramontes BE, Camilleri M, McKinzie S et al. Gender-related differences in slowing colonic transit by a 5-HT3 antagonist in subjects with diarrhea-predominant irritable bowel syndrome. Am J Gastroenterol 2001; 96: 26716.
    Direct Link:
  • 44
    Prather CM, Camilleri M, Zinsmeister AR et al. Tegaserod accelerates orocecal transit in patients with constipation-predominant irritable bowel syndrome. Gastroenterology 2000; 118: 4638.
  • 45
    Bouras EP, Camilleri M, Burton DD et al. Prucalopride accelerates gastrointestinal and colonic transit in patients with constipation without a rectal evacuation disorder. Gastroenterology 2001; 120: 35460.
  • 46
    Camilleri M, Kerstens R, Rykx A et al. A placebo-controlled trial of prucalopride for severe chronic constipation. N Engl J Med 2008; 29: 234454.
  • 47
    Camilleri M, Chang L. Challenges to the therapeutic pipeline for irritable bowel syndrome: end points and regulatory hurdles. Gastroenterology 2008; 135: 187791.
  • 48
    Deiteren A, Camilleri M, Bharucha AE et al. Performance characteristics of scintigraphic colon transit measurement in health and irritable bowel syndrome and relationship to bowel functions. Neurogastroenterol Motil 2009; in press (doi: 10.1111/j.1365-2982.2009.01441.x).