Effect of low-proof alcoholic beverages on duodenogastro-esophageal reflux in health and GERD
Article first published online: 12 OCT 2010
© 2010 Blackwell Publishing Ltd
Neurogastroenterology & Motility
Volume 23, Issue 2, pages 145–e29, February 2011
How to Cite
Seidl, H., Gundling, F., Schepp, W., Schmidt, T. and Pehl, C. (2011), Effect of low-proof alcoholic beverages on duodenogastro-esophageal reflux in health and GERD. Neurogastroenterology & Motility, 23: 145–e29. doi: 10.1111/j.1365-2982.2010.01614.x
- Issue published online: 13 JAN 2011
- Article first published online: 12 OCT 2010
- Received: 31 March 2010 Accepted for publication: 8 September 2010
- duodenogastro-esophageal reflux;
Background Alcoholic beverages are known to increase acidic gastro-esophageal reflux (GER) and the risk of esophagitis. Moreover, duodenogastro-esophageal reflux (DGER), containing bile acids, was shown to harmfully alter the esophageal mucosa, alone and synergistically with HCl and pepsin. However, studies directly addressing potential effects of different low proof alcoholic beverages on DGER in health and disease are missing.
Methods Bilitec readings for beer and white, rose, and red wine were obtained in vitro from pure and from mixtures with bile. One-hour DGER monitoring and pH-metry were performed in 12 healthy subjects and nine reflux patients with DGER after ingestion of a standardized liquid meal together with 300 mL of water, white wine, and in the volunteers, beer and rose wine.
Key Results Bilitec measurement was found to be feasible in the presence of beer, white wine, and using a threshold of 0.25, rose wine. However, the presence of red wine resulted in extinction values above this threshold. The consumption of all investigated alcoholic beverages, especially of white wine, triggered increased acidic GER, both in healthy participants and patients with reflux disease. In contrast, no relevant DGER was found after intake of alcoholic beverages.
Conclusions & Inferences Fiber-optic bilirubin monitoring can be used for DGER monitoring in combination with alcoholic beverages, except with red wine. Low-proof alcoholic beverages are a strong trigger of GER, but not of DGER, both in healthy subjects and patients with reflux disease.