Impaired gastric response to modified sham feeding in patients with postprandial distress syndrome
Article first published online: 9 NOV 2010
© 2010 Blackwell Publishing Ltd
Neurogastroenterology & Motility
Volume 23, Issue 3, pages 215–e112, March 2011
How to Cite
Manabe, N., Nakamura, K., Hara, M., Imamura, H., Kusunoki, H., Tanaka, S., Chayama, K., Hata, J. and Haruma, K. (2011), Impaired gastric response to modified sham feeding in patients with postprandial distress syndrome. Neurogastroenterology & Motility, 23: 215–e112. doi: 10.1111/j.1365-2982.2010.01622.x
- Issue published online: 8 FEB 2011
- Article first published online: 9 NOV 2010
- Received: 6 September 2010 Accepted for publication: 4 October 2010
- antral contraction;
- cardiovascular function;
- functional dyspepsia;
- modified sham feeding;
- postprandial distress syndrome
Background Impaired vagal function has been reported to be important in some patients with functional dyspepsia (FD). However, the pathophysiologic mechanisms influencing the cephalic phase of vagal activity in FD are incompletely understood. The aim of this study was to investigate the gastric response to modified sham feeding (MSF) on ultrasound and cardiovascular autonomic function in FD patients.
Methods Nineteen patients with postprandial distress syndrome (PDS, 11 men and eight women; mean age: 48.2 years) and 26 healthy subjects (HS, 13 men and 13 women; mean age: 45.0 years) were studied prospectively. Firstly, cardiovascular autonomic function was assessed by spectral analysis of RR interval variability. Antral contraction was then evaluated by ultrasonography after MSF was performed to stimulate the cephalic phase of vagal activity.
Key Results Spectral analysis of RR interval variability showed that the high-frequency component was significantly smaller in the patients than in the HS (P < 0.01). The frequency of antral contraction in response to MSF over 15 min was also significantly lower in the PDS patients than in the HS. The 15-min integrated antral contractile response (area under the contraction vs time curve) was significantly smaller in the PDS patients than in the HS (P < 0.01). Univariate analysis revealed a modest correlation between the high-frequency component of RR interval variability and the area under the contraction vs time curve (n = 46, r = 0.49, P < 0.01).
Conclusions & Inferences Autonomic abnormalities affecting the cephalic phase of vagal activity may be important in the pathogenesis of FD.