• 1
    Laranjeira C, Pachnis V. Enteric nervous system development: recent progress and future challenges. Auton Neurosci 2009; 151: 619.
  • 2
    Hotta R, Natarajan D, Thapar N. Potential of cell therapy to treat pediatric motility disorders. Semin Pediatr Surg 2009; 18: 26373.
  • 3
    Thapar N. New frontiers in the treatment of Hirschsprung disease. J Pediatr Gastroenterol Nutr 2009; 48(Suppl. 2): S924.
  • 4
    Metzger M, Caldwell C, Barlow AJ, Burns AJ, Thapar N. Enteric nervous system stem cells derived from human gut mucosa for the treatment of aganglionic gut disorders. Gastroenterology 2009; 136: 221425.e1-3.
  • 5
    Metzger M, Bareiss P, Danker T et al. Expansion and differentiation of neural progenitors derived from the human adult enteric nervous system. Gastroenterology 2009; 137: 206373.
  • 6
    Jat PS, Noble MD, Ataliotis P et al. Direct derivation of conditionally immortal cell lines from an H-2Kb-tsA58 transgenic mouse. Proc Natl Acad Sci USA 1991; 88: 5096100.
  • 7
    Morrison SJ, Csete M, Groves AK, Melega W, Wold B, Anderson DJ. Culture in reduced levels of oxygen promotes clonogenic sympathoadrenal differentiation by isolated neural crest stem cells. J Neurosci 2000; 20: 73706.
  • 8
    Bixby S, Kruger GM, Mosher JT, Joseph NM, Morrison SJ. Cell-intrinsic differences between stem cells from different regions of the peripheral nervous system regulate the generation of neural diversity. Neuron 2002; 35: 64356.
  • 9
    Kruger GM, Mosher JT, Bixby S, Joseph N, Iwashita T, Morrison SJ. Neural crest stem cells persist in the adult gut but undergo changes in self-renewal, neuronal subtype potential, and factor responsiveness. Neuron 2002; 35: 65769.
  • 10
    Kruger GM, Mosher JT, Tsai Y-H et al. Temporally distinct requirements for endothelin receptor B in the generation and migration of gut neural crest stem cells. Neuron 2003; 40: 91729.
  • 11
    Mosher JT, Yeager KJ, Kruger GM et al. Intrinsic differences among spatially distinct neural crest stem cells in terms of migratory properties, fate determination, and ability to colonize the enteric nervous system. Dev Biol 2007; 303: 115.
  • 12
    Hotta R, Anderson RB, Kobayashi K, Newgreen DF, Young HM. Effects of tissue age, presence of neurones and endothelin-3 on the ability of enteric neurone precursors to colonize recipient gut: implications for cell-based therapies. Neurogastroenterol Motil 2010; 22: 331e86.
  • 13
    Druckenbrod NR, Epstein ML. Age-dependent changes in the gut environment restrict the invasion of the hindgut by enteric neural progenitors. Development 2009; 136: 3195203.
  • 14
    Martucciello G, Brizzolara A, Favre A et al. Neural crest neuroblasts can colonise aganglionic and ganglionic gut in vivo. Eur J Pediatr Surg 2007; 17: 3440.
  • 15
    Gariepy CE, Cass DT, Yanagisawa M. Null mutation of endothelin receptor type B gene in spotting lethal rats causes aganglionic megacolon and white coat color. Proc Natl Acad Sci USA 1996; 93: 86772.
  • 16
    Nagahama M, Tsutsui Y, Ozaki T, Hama K. Myenteric and submucosal plexuses of the congenital aganglionosis rat (spotting lethal) as revealed by scanning electron microscopy. Biol Signals 1993; 2: 13645.
  • 17
    Kisseberth WC, Brettingen NT, Lohse JK, Sandgren EP. Ubiquitous expression of marker transgenes in mice and rats. Dev Biol 1999; 214: 12838.
  • 18
    Gariepy CE, Williams SC, Richardson JA, Hammer RE, Yanagisawa M. Transgenic expression of the endothelin-B receptor prevents congenital intestinal aganglionosis in a rat model of Hirschsprung disease. J Clin Invest 1998; 102: 1092101.
  • 19
    Moolenbeek C, Ruitenberg EJ. The “Swiss roll”: a simple technique for histological studies of the rodent intestine. Lab Anim 1981; 15: 579.
  • 20
    Walters LC, Cantrell VA, Weller KP, Mosher JT, Southard-Smith EM. Genetic background impacts development potential of enteric neural crest-derived progenitors in the Sox10Dom model of Hirschsprung disease. Hum Mol Genet 2010; 19: 435372.
  • 21
    Liu M-T, Kuan Y-H, Wang J, Hen R, Gershon MD. 5-HT4 receptor-mediated neuroprotection and neurogenesis in the enteric nervous system of adult mice. J Neurosci 2009; 29: 968399.
  • 22
    Veiga-Fernandes H, Coles MC, Foster KE et al. Tyrosine kinase receptor RET is a key regulator of Peyer’s patch organogenesis. Nature 2007; 446: 54751.
  • 23
    Anitha M, Joseph I, Ding X et al. Characterization of fetal and postnatal enteric neuronal cell lines with improvement in intestinal neural function. Gastroenterology 2008; 134: 142435.
  • 24
    Moriez R, Abdo H, Chaumette T, Faure M, Lardeux B, Neunlist M. Neuroplasticity and neuroprotection in enteric neurons: role of epithelial cells. Biochem Biophys Res Commun 2009; 382: 57782.
  • 25
    di Giancamillo A, Vitari F, Bosi G, Savoini G, Domeneghini C. The chemical code of porcine enteric neurons and the number of enteric glial cells are altered by dietary probiotics. Neurogastroenterol Motil 2010; 22: e2718.
  • 26
    Soret R, Chevalier J, De Coppet P et al. Short-chain fatty acids regulate the enteric neurons and control gastrointestinal motility in rats. Gastroenterology 2010; 138: 177282.
  • 27
    Chaumette T, Lebouvier T, Aubert P et al. Neurochemical plasticity in the enteric nervous system of a primate animal model of experimental Parkinsonism. Neurogastroenterol Motil 2009; 21: 21522.