• 1
    Hogan WJ, Shaker R. Medical treatment of supraesophageal complications of gastroesophageal reflux disease. Am J Med 2001; 111: 197S201S.
  • 2
    Wiener GJ, Koufman JA, Wu WC, Cooper JB, Richter JE, Castell DO. Chronic hoarseness secondary to gastroesophageal reflux disease: documentation with 24-h ambulatory pH monitoring. Am J Gastroenterol 1989; 84: 15038.
  • 3
    Katz PO. Ambulatory esophageal and hypopharyngeal pH monitoring in patients with hoarseness. Am J Gastroenterol 1990; 85: 3840.
  • 4
    Shaker R, Milbrath M, Ren J et al. Esophagopharyngeal distribution of refluxed gastric acid in patients with reflux laryngitis. Gastroenterology 1995; 109: 157582.
  • 5
    Ulualp SO, Toohill RJ, Hoffmann R, Shaker R. Pharyngeal pH monitoring in patients with posterior laryngitis. Otolaryngol Head Neck Surg 1999; 120: 6727.
  • 6
    Shaker R, Bardan E, Gu C, Kern M, Torrico L, Toohill R. Intrapharyngeal distribution of gastric acid refluxate. Laryngoscope 2003; 113: 118291.
  • 7
    Kawamura O, Aslam M, Rittmann T, Hofmann C, Shaker R. Physical and pH properties of gastroesophagopharyngeal refluxate: a 24-hour simultaneous ambulatory impedance and pH monitoring study. Am J Gastroenterol 2004; 99: 100010.
    Direct Link:
  • 8
    Kawamura O, Bajaj S, Aslam M, Hofmann C, Rittmann T, Shaker R. Impedance signature of pharyngeal gaseous reflux. Eur J Gastroenterol Hepatol 2007; 19: 6571.
  • 9
    Koufman JA. The otolaryngologic manifestations of gastroesophageal reflux disease (GERD): a clinical investigation of 225 patients using ambulatory 24-hour pH monitoring and an experimental investigation of the role of acid and pepsin in the development of laryngeal injury. Laryngoscope 1991; 101(Suppl. 53): 178.
  • 10
    Book DT, Rhee JS, Toohill RJ, Smith TL. Perspectives in laryngopharyngeal reflux: an international survey. Laryngoscope 2002; 112: 1399406.
  • 11
    Hicks DM, Ours TM, Abelson TI, Vaezi MF, Richter JE. The prevalence of hypopharynx findings associated with gastroesophageal reflux in normal volunteers. J Voice 2002; 16: 56479.
  • 12
    Wo JM, Grist WJ, Gussack G, Delgaudio JM, Waring JP. Empiric trial of high-dose omeprazole in patients with posterior laryngitis: a prospective study. Am J Gastroenterol 1997; 92: 21605.
  • 13
    Ormseth EJ, Wong RK. Reflux laryngitis: pathophysiology, diagnosis, and management. Am J Gastroenterol 1999; 94: 28127.
    Direct Link:
  • 14
    Richter JE, Hicks DM. Unresolved issues in gastroesophageal reflux-related ear, nose, and throat problems. Am J Gastroenterol 1997; 92: 21434.
  • 15
    Irwin RS, Boulet LP, Cloutier MM et al. Managing cough as a defense mechanism and as a symptom. A consensus panel report of the American College of Chest Physicians. Chest 1998; 114(Suppl. 2): 133S81S.
  • 16
    Palombini BC, Villanova CA, Araújo E et al. A pathogenic triad in chronic cough: asthma, postnasal drip syndrome, and gastroesophageal reflux disease. Chest 1999; 116: 27984.
  • 17
    O’Connell F, Thomas VE, Pride NB, Fuller RW. Capsaicin cough sensitivity decreases with successful treatment of chronic cough. Am J Respir Crit Care Med 1994; 150: 37480.
  • 18
    Kastelik JA, Aziz I, Ojoo JC, Thompson RH, Redington AE, Morice AH. Investigation and management of chronic cough using a probability-based algorithm. Eur Respir J 2005; 25: 23543.
  • 19
    Poe RH, Kallay MC. Chronic cough and gastroesophageal reflux disease: experience with specific therapy for diagnosis and treatment. Chest 2003; 123: 67984.
  • 20
    Ours TM, Kavuru MS, Schilz RJ, Richter JE. A prospective evaluation of esophageal testing and a double-blind, randomized study of omeprazole in a diagnostic and therapeutic algorithm for chronic cough. Am J Gastroenterol 1999; 94: 31318.
    Direct Link:
  • 21
    Kiljander TO, Salomaa ER, Hietanen EK, Terho EO. Chronic cough and gastro-oesophageal reflux: a double-blind placebo-controlled study with omeprazole. Eur Respir J 2000; 16: 6338.
  • 22
    Tutuian R, Mainie I, Agrawal A, Adams D, Castell DO. Nonacid reflux in patients with chronic cough on acid-suppressive therapy. Chest 2006; 130: 38691.
  • 23
    Sifrim D, Dupont L, Blondeau K, Zhang X, Tack J, Janssens J. Weakly acidic reflux in patients with chronic unexplained cough during 24 hour pressure, pH, and impedance monitoring. Gut 2005; 54: 44954.
  • 24
    Vakil N, van Zanten SV, Kahrilas P, Dent J, Jones R; Global Consensus Group. The Montreal definition and classification of gastroesophageal reflux disease: a global evidence-based consensus. Am J Gastroenterol 2006; 101: 190020.
    Direct Link:
  • 25
    Hongo M. Minimal changes in reflux esophagitis: red ones and white ones. J Gastroenterol 2006; 41: 959.
  • 26
    Kusano M, Shimoyama Y, Sugimoto S et al. Development and evaluation of FSSG: frequency scale for the symptoms of GERD. J Gastroenterol 2004; 39: 88891.
  • 27
    Silny J. Intraluminal multiple electric impedance procedure for measurement of gastrointestinal motility. J Gastrointest Motil 1991; 3: 15162.
  • 28
    Silny J, Knigge KP, Fass J, Rau G, Matern S, Schumpelick V. Verification of the intraluminal multiple electrical impedance measurement for the recording of gastrointestinal motility. J Gastrointest Motil 1993; 5: 10722.
  • 29
    Fass J, Silny J, Braun J et al. Measuring esophageal motility with a new intraluminal impedance device. First clinical results in reflux patients. Scand J Gastroenterol 1994; 29: 693702.
  • 30
    Shaker R, Dodds WJ, Hogan WJ, Arndoefer RC, Hofmann C, Dent J. Mechanisms of esophagopharyngeal acid regurgitation. Gastroenterology 1991; 100: A494.
  • 31
    Ulualp SO, Toohill RJ, Kern M, Shaker R. Pharyngo-US contractile reflex in patients with posterior laryngitis. Laryngoscope 1998; 108: 13547.
  • 32
    Kawamura O, Easterling C, Aslam M, Rittmann T, Hofmann C, Shaker R. Laryngo-upper esophageal sphincter contractile reflex in humans deteriorates with age. Gastroenterology 2004; 127: 5764.
  • 33
    Ing AJ, Ngu MC, Breslin AB. Chronic persistent cough and gastro-oesophageal reflux. Thorax 1991; 46: 47983.
  • 34
    Lam HG, Breumelhof R, Roelofs JM, Van Berge Henegouwen GP, Smout AJ. What is the optimal time window in symptom analysis of 24-hour esophageal pressure and pH data? Dig Dis Sci 1994; 39: 4029.
  • 35
    Weusten BL, Roelofs JM, Akkermans LM, Van Berge-Henegouwen GP, Smout AJ. The symptom-association probability: an improved method for symptom analysis of 24-hour esophageal pH data. Gastroenterology 1994; 107: 17415.
  • 36
    Jacob P, Kahrilas PJ, Herzon G. Proximal esophageal pH-metry in patients with ‘reflux laryngitis’. Gastroenterology 1991; 100: 30510.
  • 37
    Cool M, Poelmans J, Feenstra L, Tack J. Characteristics and clinical relevance of proximal esophageal pH monitoring. Am J Gastroenterol 2004; 99: 231723.
    Direct Link: