Intragastric pressure during food intake: a physiological and minimally invasive method to assess gastric accommodation
Article first published online: 7 FEB 2011
© 2011 Blackwell Publishing Ltd
Neurogastroenterology & Motility
Volume 23, Issue 4, pages 316–e154, April 2011
How to Cite
Janssen, P., Verschueren, S., Giao Ly, H., Vos, R., Van Oudenhove, L. and Tack, J. (2011), Intragastric pressure during food intake: a physiological and minimally invasive method to assess gastric accommodation. Neurogastroenterology & Motility, 23: 316–e154. doi: 10.1111/j.1365-2982.2011.01676.x
- Issue published online: 11 MAR 2011
- Article first published online: 7 FEB 2011
- Received: 3 December 2010 Accepted for publication: 3 January 2011
- gastric accommodation;
- healthy volunteers;
- intragastric pressure
Background The stomach relaxes upon food intake and thereby provides a reservoir while keeping the intragastric pressure (IGP) low. We set out to determine whether we could use IGP as a measurement for stomach accommodation during food intake.
Methods In fasted healthy volunteers (n = 7–17) a manometer and an infusion catheter were positioned in the proximal stomach. After a stabilization period a nutrient drink was intragastrically infused at 15, 30 and 60 mL min−1. To investigate the effect of impaired accommodation the effect of NG-monomethyl-l-arginine (L-NMMA) was examined. The volunteers scored satiation until maximum, when the experiment ended. The IGP was presented as a change from baseline (mean ± SEM) and compared with repeated measures anova.
Key Results Independent on the ingestion speed, the IGP decreased initially and gradually increased thereafter. Volunteers scored maximal satiation after 699 ± 62, 809 ± 90 and 997 ± 120 mL nutrient drink infused (15, 30 and 60 mL min−1 respectively; P < 0.01). Maximum IGP decrease was 3.4 ± 0.5 mmHg after 205 ± 28 mL, 5.1 ± 0.7 mmHg after 212 ± 46 mL, and 5.2 ± 0.7 mmHg after 296 ± 28 mL infused volume [15, 30 and 60 mL min−1 respectively; not significant (ns)]. Post hoc analysis showed significant correlations between IGP and satiation score increase. During L-NMMA infusion IGP was significantly increased while subjects drank significantly less (816 ± 91 vs 1032 ± 71 mL; P < 0.005). Interestingly, the correlation between IGP increase and satiation score increase did not differ after L-NMMA treatment.
Conclusions & Inferences The IGP during nutrient drink ingestion provides a minimally invasive alternative to the barostat for the assessment of gastric accommodation. These findings furthermore indicate that IGP is a major determinant of satiation.