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Movie S1. Demonstration of propulsive motility in a segment of normal guinea pig distal colon before and after the addition of 1.0 μmol L1 veratridine. In normal Kreb’s solution, the fecal pellet progresses through the segment of colon with a linear time–distance relationship. Following addition of veratridine, the fecal pellet does not make forward progress, indicating the neural elements of the preparation are not capable of generating a pressure gradient to propel the pellet in an oral to anal direction. In the presence of veratridine, contractile activity is still detectable, confirming the viability of the preparation. The movie is shown at four times normal speed.

Movie S2. Demonstration of propulsive motility in a segment of TNBS-inflamed guinea pig distal colon before and after the addition of 10 μmol L1 ZD7288. In this segment of colon, the fecal pellet is propelled in an aboral direction, but its progress is obstructed in the region of an ulcer. Following addition of ZD7288 to the bathing solution, the fecal pellet progresses through the entire segment of colon, including the ulcerated region, with a fairly linear time–distance relationship. The movie is shown at four times normal speed.

FilenameFormatSizeDescription
NMO_1702_sm_VideoS1.m4v1186KSupporting info item
NMO_1702_sm_VideoS2.m4v3204KSupporting info item

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