Electroanalytical approaches to study signaling mechanisms in the gastrointestinal tract


Address for Correspondence
Bhavik Anil Patel, Centre for Biomedical and Health Sciences Research, School of Pharmacy and Biomolecular Sciences, University of Brighton, Huxley Building, Lewes Road, BN2 4GJ Brighton, UK.
Tel: +44 1273 642418; fax: +44 1273 649333;
e-mail: b.a.patel@brighton.ac.uk


Electroanalytical techniques over the past few years have been applied to study real-time release of various signaling molecules in the GI tract. These approaches have become highly attractive as they provide dynamic spatial information on the amount of signaling molecules released. Although these approaches are relatively new to the field, the studies to date have provided useful insights into the alterations in signaling mechanisms during maturation, obesity and in a model of colitis. New methods and techniques have also allowed the possibility to obtain information on the signaling process and future developments will provide a wide diverse array of information that will be of benefit to all researchers in the field of gastroenterology. This review focuses on the types of techniques utilized, the information they can provide, their potential advantages and disadvantages in monitoring signaling processes in the gastrointestinal tract, the existing scientific studies that have utilized electroanalytical methods to date and the future potential impact of such approaches.