Cyclic vomiting syndrome and functional vomiting in adults: association with cannabinoid use in males
Article first published online: 27 SEP 2011
© 2011 Blackwell Publishing Ltd
Neurogastroenterology & Motility
Volume 24, Issue 1, pages 20–e1, January 2012
How to Cite
Choung, R. S., Locke, G. R., Lee, R. M., Schleck, C. D., Zinsmeister, A. R. and Talley, N. J. (2012), Cyclic vomiting syndrome and functional vomiting in adults: association with cannabinoid use in males. Neurogastroenterology & Motility, 24: 20–e1. doi: 10.1111/j.1365-2982.2011.01791.x
- Issue published online: 21 DEC 2011
- Article first published online: 27 SEP 2011
- Received: 1 March 2011 Accepted for publication: 27 August 2011
- cyclic vomiting syndrome;
- functional vomiting;
- male cannabinoid user
Background Cyclic vomiting syndrome (CVS) is characterized by stereotypical episodes of vomiting separated by symptom-free intervals. However, the difficulty encountered in the management of patients with CVS may be a reflection of a deficiency in our understanding of the disorder. We aimed to evaluate whether clinical or gastric emptying (GE) data discriminate patients labeled as having CVS from functional vomiting (FV) or irritable bowel syndrome (IBS).
Methods The medical records of patients diagnosed with any vomiting (including CVS, FV) over a 13-year period (1993–2006) at our institution were carefully reviewed. Disease controls were age and gender matched subjects with IBS. Gastric emptying was performed by scintigraphy (99mTc-egg meal). The associations of clinical factors and GE data with patient status (CVS vs FV or IBS) were analyzed.
Key Results A total of 82 patients with CVS and 62 FV patients were identified. Younger age [per 10 years, OR = 0.7 (0.5, 0.9)], male gender [OR = 0.4 (0.2, 0.9)], and cannabinoid use [OR = 2.9 (1.2, 7.2)] were significantly associated with CVS compared with FV. However, there were no significant associations between patient status (CVS vs FV) and age, BMI, smoking, alcohol use, gastrointestinal symptoms, or GE. The proportion of cannabinoid users was significantly higher in patients with CVS compared with patients with IBS, whereas proportions for headaches and psychiatric disease were higher in subjects with IBS.
Conclusions & Inferences Cyclic vomiting syndrome (vs FV) was not associated with clinical factors, but was associated with younger age, male gender and cannabinoid use. A larger proportion of CVS (vs IBS) patients had used cannabinoids.