• 1
    Levenstein S. Peptic ulcer at the end of the 20th century: biological and psychological risk factors. Can J Gastroenterol 1999; 13: 7539.
  • 2
    Quan C, Talley NJ. Management of peptic ulcer disease not related to Helicobacter pylori or NSAIDs. Am J Gastroenterol 2002; 97: 295061.
    Direct Link:
  • 3
    Yuan Y, Padol IT, Hunt RH. Peptic ulcer disease today. Nat Clin Pract Gastroenterol Hepatol 2006; 3: 809.
  • 4
    Overstreet DH, Friedman E, Mathe AA, Yadid G. The Flinders Sensitive Line rat: a selectively bred putative animal model of depression. Neurosci Biobehav Rev 2005; 29: 73959.
  • 5
    Jones MP. The role of psychosocial factors in peptic ulcer disease: beyond Helicobacter pylori and NSAIDs. J Psychosom Res 2006; 60: 40712.
  • 6
    Levenstein S. Psychosocial factors in peptic ulcer and inflammatory bowel disease. J Consult Clin Psychol 2002; 70: 73950.
  • 7
    Overstreet DH. The Flinders sensitive line rats: a genetic animal model of depression. Neurosci Biobehav Rev 1993; 17: 5168.
  • 8
    Janowsky DS, el Yousef MK, Davis JM, Sekerke HJ. A cholinergic-adrenergic hypothesis of mania and depression. Lancet 1972; 2: 6325.
  • 9
    Russell RW, Overstreet DH, Messenger M, Helps SC. Selective breeding for sensitivity to DFP: generalization of effects beyond criterion variables. Pharmacol Biochem Behav 1982; 17: 88591.
  • 10
    Black SA, Goodwin JS, Markides KS. The association between chronic diseases and depressive symptomatology in older Mexican Americans. J Gerontol A Biol Sci Med Sci 1998; 53: M188M94.
  • 11
    Levenstein S, Kaplan GA, Smith MW. Psychological predictors of peptic ulcer incidence in the Alameda County Study. J Clin Gastroenterol 1997; 24: 1406.
  • 12
    Kubacki A. Peptic ulcer and emotional disorders. Psychiatr Pol 1968; 2: 6116.
  • 13
    Feldman M, Walker P, Green JL, Weingarden K. Life events stress and psychosocial factors in men with peptic ulcer disease. A multidimensional case-controlled study. Gastroenterology 1986; 91: 13709.
  • 14
    Alp MH, Court JH, Grant AK. Personality pattern and emotional stress in the genesis of gastric ulcer. Gut 1970; 11: 7737.
  • 15
    MacKay J, Hajnsek F. An unusual case of bleeding peptic ulcer with masked psychotic depression. Can Med Assoc J 1960; 82: 4245.
  • 16
    Guldahl M. The effect of trimipramine (Surmontil r) on masked depression in patients with duodenal ulcer. A double-blind study. Scan J Gastroenterol Suppl 1977; 43: 2731.
  • 17
    Levin A, Katzeff IE, Schlebusch L et al. A psychophysiological hypothesis on the aetiology of duodenal ulceration. Med Hypotheses 1980; 6: 98795.
  • 18
    Molinder H, Wallander MA, Hallberg M, Bodemar G. Dyspepsia--acid or stress? A study of controversy. Abandoned by experts, finalized in clinical practice? Scand J Gastroenterol 1999; 34: 105764.
  • 19
    Debas HT, Carvajal SH. Vagal regulation of acid secretion and gastrin release. Yale J Biol Med 1994; 67: 14551.
  • 20
    Lloyd KC, Raybould HE, Tache Y, Walsh JH. Role of gastrin, histamine, and acetylcholine in the gastric phase of acid secretion in anesthetized rats. Am J Physiol 1992; 262: G74755.
  • 21
    Tougas G, Yuan LY, Radamaker JW, Chiverton SG, Hunt RH. Effect of acupuncture on gastric acid secretion in healthy male volunteers. Dig Dis Sci 1992; 37: 157682.
  • 22
    Lux G, Hagel J, Backer P et al. Acupuncture inhibits vagal gastric acid secretion stimulated by sham feeding in healthy subjects. Gut 1994; 35: 10269.
  • 23
    Collen MJ, Ciarleglio CA, Stanczak VJ, Treem WR, Lewis JH. Basal gastric acid secretion in children with atypical epigastric pain. Am J Gastroenterol 1988; 83: 9236.
  • 24
    Shay H, Sun DCH, Gruenstein M. A quantitative method for measuring spontaneous gastric secretion in the rat. Gastroenterology 1954; 26: 90613.
  • 25
    Brodie DA. The mechanism of gastric hyperacidity produced by pylorus ligation in the rat. Am J Dig Dis 1966; 11: 23141.
  • 26
    Azerkan L, Bengtsson P, Tommeras K, Li ZQ, Mardh S. Characterization of oxyntic glands isolated from the rat gastric mucosa. Com Biochem Physiol A Mol Integr Physiol 2001; 128: 34957.
  • 27
    Padol IT, Hunt RH. Effect of Th1 cytokines on acid secretion in pharmacologically characterised mouse gastric glands. Gut 2004; 53: 107581.
  • 28
    Wallace JL, Keenan CM, Cucala M, Mugridge KG, Parente L. Mechanisms underlying the protective effects of interleukin 1 in experimental nonsteroidal anti-inflammatory drug gastropathy. Gastroenterology 1992; 102: 117685.
  • 29
    Takagi K, Okabe S. The effects of drugs on the production and recovery processes of the stress ulcer. Jpn J Pharmacol 1968; 18: 918.
  • 30
    Savarino V, Mela GS, Zentilin P et al. Effect of one-month treatment with nonsteroidal antiinflammatory drugs (NSAIDs) on gastric pH of rheumatoid arthritis patients. Dig Dis Sci 1998; 43: 45963.
  • 31
    Feldman M, Colturi TJ. Effect of indomethacin on gastric acid and bicarbonate secretion in humans. Gastroenterology 1984; 87: 133943.
  • 32
    Levine RA, Schwartzel EH. Effect of indomethacin on basal and histamine stimulated human gastric acid secretion. Gut 1984; 25: 71822.
  • 33
    Juby A, Davis P. Psychological profiles of patients with upper gastrointestinal symptomatology induced by non-steroidal anti-inflammatory drugs. Ann Rheum Dis 1991; 50: 21113.
  • 34
    Li YM, Lu GM, Zou XP, Li ZS, Peng GY, Fang DC. Dynamic functional and ultrastructural changes of gastric parietal cells induced by water immersion-restraint stress in rats. World J Gastroenterol 2006; 12: 336872.
  • 35
    Xie YF, Jiao Q, Guo S, Wang FZ, Cao JM, Zhang ZG. Role of parasympathetic overactivity in water immersion stress-induced gastric mucosal lesion in rat. J Appl Physiol 2005; 99: 241622.
  • 36
    Gaton J, Fernandez dlG, Velasco A. The role of the neurotransmitters acetylcholine and noradrenaline in the pathogenesis of stress ulcers. Com Biochem Physiol C 1993; 106: 1259.
  • 37
    Hashiguchi J, Ito M, Sekine I. The effect of the autonomic nervous system on cell proliferation of the gastric mucosa in stress ulcer formation. J Auton Nerv Sys 1993; 43: 17987.
  • 38
    Pare WP, Redei E. Depressive behavior and stress ulcer in Wistar Kyoto rats. J Physiol 1993; 87: 22938.
  • 39
    Pare WP. Learning behavior, escape behavior, and depression in an ulcer susceptible rat strain. Integr Physiol Behav Sci 1992; 27: 13041.
  • 40
    Shichijo K, Ito M, Taniyama K, Sekine I. The role of sympathetic neurons for low susceptibility to stress in gastric lesions. Life Sci 1993; 53: 2617.
  • 41
    Ito M, Shichijo K, Sekine I, Ozaki M. Different susceptibility of stress-induced gastric ulcer and the autonomic nervous function in the hereditary hypertensive rats. J Auton Nerv Syst 1994; 46: 22936.
  • 42
    Ekelund M, Hakanson R, Vallgren S. Effects of cimetidine, atropine and pirenzepine on basal and stimulated gastric acid secretion in the rat. Eur J Pharmacol 1987; 138: 22532.
  • 43
    Welsh NJ, Shankley NP, Black JW. Comparative analysis of the vagal stimulation of gastric acid secretion in rodent isolated stomach preparations. Br J Pharmacol 1994; 112: 936.
  • 44
    Riedel R, Bohnenkamp W, Eltze M, Heintze K, Prinz W, Kromer W. Comparison of the gastric antisecretory and antiulcer potencies of telenzepine, pirenzepine, ranitidine and cimetidine in the rat. Digestion 1988; 40: 2532.
  • 45
    Sandvik AK, Marvik R, Dimaline R, Waldum HL. Carbachol stimulation of gastric acid secretion and its effects on the parietal cell. Br J Pharmacol 1998; 124: 6974.
  • 46
    Vagne M, Fargier MC, Desvigne A, Daniere S, Lambert R. Gastric acid secretion in different strains of rats during pyloric ligation and cholinergic stimulation. Digestion 1973; 8: 30816.
  • 47
    Alumets J, Ekelund M, Hakanson R et al. Gastric acid response to pylorus ligation in rats: is gastrin or histamine involved? J Physiol 1982; 323: 14556.
  • 48
    Hakanson R, Hedenbro J, Liedberg G, Sundler F, Vallgren S. Mechanisms of gastric acid secretion after pylorus and oesophagus ligation in the rat. J Physiol 1980; 305: 13949.
  • 49
    Nishida A, Uchida-Kobayashi A, Takemoto Y, Akuzawa S, Miyata K. Comparative evaluation of the role of endogenous gastrin in basal acid secretion in conscious rats provided with chronic fistula and pylorus ligation. Jpn J Pharmacol 1996; 71: 22330.
  • 50
    Pober Z. An explanation of gastric hypersecretion in the pylorus-ligated rat. Arch Physiol Biochem 1999; 107: 37682.
  • 51
    Demling L, Riemann JF, Schmidt H, Richter K. Experimental evidence for an ‘internal leak’ of cat gastric mucosa after stimulation with histamine and carbachol. Hepatogastroenterology 1982; 29: 6871.
  • 52
    Wyatt MA, Jarvie E, Feniuk W, Humphrey PP. Somatostatin sst2 receptor-mediated inhibition of parietal cell function in rat isolated gastric mucosa. Br J Pharmacol 1996; 119: 90510.
  • 53
    Yukinaka M, Nomura M, Saijyo T et al. Evaluation of autonomic nervous function in patients with essential hypertension complicated with peptic ulcer. J Gastroenterol Hepatol 2000; 15: 404.
  • 54
    Hirschowitz BI, Helman CA. Effects of fundic vagotomy and cholinergic replacement on pentagastrin dose responsive gastric acid and pepsin secretion in man. Gut 1982; 23: 67582.
  • 55
    Hoq MN, Deepak KK, Sharma MP, Bijlani RL. Lowered sympathetic reactivity in patients with non-bleeding duodenal ulcers. Indian J Gastroenterol 1999; 18: 1124.
  • 56
    Ma J, Vaillancourt R, Boddam R, Auger S, Sampalis J. Association between antidepressant use and prescribing of gastric acid suppressants. Can J Psychiatry 2006; 51: 17884.
  • 57
    Sen T, Abdulsalam CA, Pal S et al. Effect of amitriptyline on gastric ulceration. Fundam Clin Pharmacol 2002; 16: 3115.
  • 58
    Ries RK, Gilbert DA, Katon W. Tricyclic antidepressant therapy for peptic ulcer disease. Arch Intern Med 1984; 144: 5669.
  • 59
    Ray A, Sullivan RM, Henke PG. Adrenergic modulation of gastric stress pathology in rats: a cholinergic link. J Auton Nerv Syst 1987; 20: 2658.
  • 60
    Feldman M. Inhibition of gastric acid secretion by selective and nonselective anticholinergics. Gastroenterology 1984; 86: 3616.
  • 61
    Johansson I, Lundell L, Svensson SE. Inhibition of gastric secretion by atropine in conscious rats. J Physiol 1971; 217: 72335.
  • 62
    Bresnick WH, Rask-Madsen C, Hogan DL, Koss MA, Isenberg JI. The effect of acute emotional stress on gastric acid secretion in normal subjects and duodenal ulcer patients. J Clin Gastroenterol 1993; 17: 11722.
  • 63
    Pielecka Z, Hanzlik J, Gorny D, Jakiel A. Vegetative nervous system’s contribution to the development of stress induced gastric ulcers. Pol Tyg Lek 1991; 46: 8658.
  • 64
    Talley NJ, Fung LH, Gilligan IJ, McNeil D, Piper DW. Association of anxiety, neuroticism, and depression with dyspepsia of unknown cause. A case-control study. Gastroenterology 1986; 90: 88692.
  • 65
    Tennant C, Goulston K, Langeluddecke P. Psychological correlates of gastric and duodenal ulcer disease. Psychol Med 1986; 16: 36571.
  • 66
    Criollos TO, Frati Munari AC, Flores Suarez RE, Martinez PE. Chronic peptic ulcer among students and adolescents. Bol Med Hosp Infant Mex 1978; 35: 2332.
  • 67
    Norton GR, Norton PJ, Asmundson GJ, Thompson LA, Larsen DK. Neurotic butterflies in my stomach: the role of anxiety, anxiety sensitivity and depression in functional gastrointestinal disorders. J Psychosom Res 1999; 47: 23340.
  • 68
    Hochstrasser B, Angst J. The Zurich Study: XXII. Epidemiology of gastrointestinal complaints and comorbidity with anxiety and depression. Eur Arch Psychiatry Clin Neurosci 1996; 246: 26172.
  • 69
    Levenstein S, Prantera C, Varvo V et al. Long-term symptom patterns in duodenal ulcer: psychosocial factors. J Psychosom Res 1996; 41: 46572.
  • 70
    Dinan TG, Scott LV, Brady D, McNamara D, Keeling PW. Altered hypothalamic cholinergic responses in patients with nonulcer dyspepsia: a study of pyridostigmine-stimulated growth hormone release. Am J Gastroenterol 2002; 97: 193740.
    Direct Link:
  • 71
    Mattsson H, Arani Z, Astin M, Bayati A, Overstreet DH, Lehmann A. Altered neuroendocrine response and gastric dysmotility in the Flinders Sensitive Line rat. Neurogastroenterol Motil 2005; 17: 16674.