Weak and absent peristalsis


Address for Correspondence
André Smout MD, PhD, Department of Gastroenterology and Hepatology, Academic Medical Center, PO Box 22700, 1100 DE, Amsterdam, The Netherlands.
Tel: +31 20 5669111; fax: +31 20 6917033; e-mail: a.j.smout@amc.uva.nl


Background  Weak and absent esophageal peristalsis are frequently encountered esophageal motility disorders, which may be associated with dysphagia and which may contribute to gastroesophageal reflux disease. Recently, rapid developments in the diagnostic armamentarium have taken place, in particular, in high-resolution manometry with or without concurrent intraluminal impedance monitoring.

Purpose  This article aims to review the current insights in the terminology, pathology, pathophysiology, clinical manifestations, diagnostic work-up,and management of weak and absent peristalsis.