Overlap of dyspepsia and gastroesophageal reflux in the general population: one disease or distinct entities?
Version of Record online: 12 DEC 2011
© 2011 Blackwell Publishing Ltd
Neurogastroenterology & Motility
Volume 24, Issue 3, pages 229–e106, March 2012
How to Cite
Choung, R. S., Locke, G. R., Schleck, C. D., Zinsmeister, A. R. and Talley, N. J. (2012), Overlap of dyspepsia and gastroesophageal reflux in the general population: one disease or distinct entities?. Neurogastroenterology & Motility, 24: 229–e106. doi: 10.1111/j.1365-2982.2011.01845.x
- Issue online: 8 FEB 2012
- Version of Record online: 12 DEC 2011
- Received: 12 August 2011 Accepted for publication: 1 November 2011
- gastroesophageal reflux;
- population-based study
Background The overlap of dyspepsia and gastroesophageal reflux (GER) is known to be frequent, but whether the overlap group is a distinct entity or not remains unclear. The aims of the study was to evaluate whether the overlap of dyspepsia and GER (dyspepsia-GER overlap) occurs more than expected due to chance alone, and evaluate the risk factors for dyspepsia-GER overlap.
Methods In 2008 and 2009, a validated Bowel Disease Questionnaire was mailed to a total of 8006 community sample from Olmsted County, MN. Overall, 3831 of the 8006 subjects returned surveys (response rate 48%). Dyspepsia was defined by symptom criteria of Rome III; GER was defined by weekly or more frequent heartburn and/or acid regurgitation.
Key Results Dyspepsia and GER occurred together more commonly than expected by chance. The somatic symptom checklist score was significantly associated with dyspepsia-GER overlap vs GER alone or dyspepsia alone [OR = 1.9 (1.4, 2.5), and 1.6 (1.2, 2.1), respectively]. Insomnia was also significantly associated with dyspepsia-GER overlap vs. GER alone or dyspepsia alone [OR = 1.4 (1.1, 1.7), OR = 1.3 (1.1, 1.6), respectively]. Moreover, proton pump inhibitor use was significantly associated with dyspepsia-GER overlap vs dyspepsia alone [OR = 2.4 (1.5, 3.8)].
Conclusions & Inferences Dyspepsia-GER overlap is common in the population and is greater than expected by chance.