Heart rate variability in the irritable bowel syndrome: a review of the literature
Version of Record online: 19 JAN 2012
© 2012 Blackwell Publishing Ltd
Neurogastroenterology & Motility
Volume 24, Issue 3, pages 206–216, March 2012
How to Cite
Mazurak, N., Seredyuk, N., Sauer, H., Teufel, M. and Enck, P. (2012), Heart rate variability in the irritable bowel syndrome: a review of the literature. Neurogastroenterology & Motility, 24: 206–216. doi: 10.1111/j.1365-2982.2011.01866.x
- Issue online: 8 FEB 2012
- Version of Record online: 19 JAN 2012
- Received: 9 August 2011 Accepted for publication: 18 December 2011
- autonomic nerve system;
- heart rate variability;
- irritable bowel syndrome
Background Patients with irritable bowel syndrome (IBS) often present with disturbances of bowel habits (diarrhea, constipation) and abdominal pain/discomfort that are modulated by the autonomic nerve system (ANS). In this narrative review, we analyzed studies that measured ANS functioning in IBS by means of heart rate variability (HRV).
Methods The PUBMED was searched with the keywords ‘irritable bowel syndrome’ AND (‘heart rate variability’ OR ‘autonomic function’). We included only papers that used ‘traditional’ HRV indices and diagnosed IBS based on Manning or Rome criteria. Studies were sub-grouped according to methodological features of HRV analysis (24-h monitoring, short-term laboratory records, records during sleep).
Key Results Most studies reported no difference in HRV when the IBS population was compared to healthy controls. Dividing the IBS sample into subgroups – according to their predominant bowel symptoms, the severity of clinical course, the presence of depressive symptoms, or a history of abuse in the past – revealed changes in autonomic functioning.
Conclusions & Inferences Patients with IBS appear to experience symptoms that may be the result of changes in ANS functioning. HRV measures in clinical routine may allow assessing these changes, but further studies performed in a standardized fashion should improve the validity of HRV measures for clinical research first.