• 1
    Delattre JF, Palot JP, Ducasse A, Flament JB, Hureau J. The crura of the diaphragm and diaphragmatic passage. Applications to the gastroesophageal reflux, its investigation and treatment. Anat Clin 1985; 7: 27183.
  • 2
    Kwok H, Marriz Y, Al-Ali S, Windsor JA. Phrenoesophageal ligament re-visited. Clin Anat 1999; 12: 16470.
  • 3
    Kahrilas PJ, Lin S, Chen J, Manka M. The effect of hiatus hernia on gastro-esophageal junction pressure. Gut 1999; 44: 47682.
  • 4
    McColl KE, Clarke A, Seenan J. Acid pocket, hiatus hernia and acid reflux. Gut 2010; 59: 4301.
  • 5
    Kahrilas PJ, Dodds WJ, Hogan WJ. Effect of peristaltic dysfunction on esophageal volume clearance. Gastroenterology 1988; 94: 7380.
  • 6
    Bredenoord AJ, Weusten BL, Timmer R, Smout AJ. Intermittent spatial separation of diaphragm and lower esophageal sphincter favors acidic and weakly acidic reflux. Gastroenterology 2006; 130: 33440.
  • 7
    Bredenoord AJ, Weusten BL, Carmagnola S, Smout AJ. Double peaked high pressure zone at the esophagogastric junction in controls and in patients with a hiatal hernia: a study using high-resolution manometry. Dig Dis Sci 2004; 49: 112835.
  • 8
    Pandolfino JE, Zhang QG, Ghosh SK, Han A, Boniquit C, Kahrilas PJ. Transient lower esophageal sphincter relaxations and reflux: mechanistic analysis using concurrent fluoroscopy and high resolution manometry. Gastroenterology 2006; 131: 172533.
  • 9
    Babaei A, Bhargava V, Korsapati H, Zheng WH, Mittal RK. A unique longitudinal muscle contraction pattern associated with transient lower esophageal sphincter relaxation. Gastroenterology 2008; 134: 132231.
  • 10
    Scheffer RC, Akkermans LM, Bais JE, Roelofs JM, Smout AJ, Gooszen HG. Elicitation of transient lower esophageal sphincter relaxations in response to gastric distension and meal ingestion. Neurogastroenterol Motil 2002; 14: 64755.
  • 11
    Sifrim D, Holloway R. Transient lower esophageal sphincter relaxations: how many or how harmful? Am J Gastroenterol 2001; 96: 252932.
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  • 12
    Mittal RK, Holloway RH, Penagini R, Blackshaw LA, Dent J. Transient lower esophageal sphincter relaxation. Gastroenterology 1995; 109: 60110.
  • 13
    Lee YY, Seenan JP, Whiting JG et al. Development and validation of a probe allowing accurate and continuous monitoring of location of squamo-columnar junction. Med Eng Phys 2012; 34: 27989.
  • 14
    Pandolfino JE, El-Serag HB, Zhang Q, Shah N, Ghosh SK, Kahrilas PJ. Obesity: a challenge to esophagogastric junction integrity. Gastroentero-logy 2006; 130: 63949.
  • 15
    Robertson EV, Lee YY, Derakhshan MH et al. High-resolution esophageal manometry: addressing thermal drift of the manoscan system. Neurogastroenterol Motil 2012; 24: 61-e11.
  • 16
    Holloway RH, Penagini R, Ireland AC. Criteria for objective definition of transient lower esophageal sphincter relaxation. Am J Physiol 1995; 268(1 Pt 1): G12833.
  • 17
    Kuribayashi S, Massey BT, Hafeezullah M et al. Terminating motor events for TLESR are influenced by the presence and distribution of refluxate. Am J Physiol Gastrointest Liver Physiol 2009; 297: G715.
  • 18
    Dogan I, Bhargava V, Liu J, Mittal RK. Axial stretch: A novel mechanism of the lower esophageal sphincter relaxation. Am J Physiol Gastrointest Liver Physiol 2007; 292: G32934.
  • 19
    Jiang Y, Bhargava V, Mittal RK. Mechanism of stretch-activated excitatory and inhibitory responses in the lower esophageal sphincter. Am J Physiol Gastrointest Liver Physiol 2009; 297: G397405.
  • 20
    Mittal RK, Fisher MJ. Electrical and mechanical inhibition of the crural diaphragm during transient relaxation of the lower esophageal sphincter. Gastroenterology 1990; 99: 12658.
  • 21
    Sugarbaker DJ, Rattan S, Goyal RK. Mechanical and electrical activity of esophageal smooth muscle during peristalsis. Am J Physiol 1984; 246(2 Pt 1): G14550.
  • 22
    Yamamoto Y, Liu J, Smith TK, Mittal RK. Distension-related responses in circular and longitudinal muscle of the human esophagus: an ultrasonographic study. Am J Physiol 1998; 275(4 Pt 1): G80511.
  • 23
    Altschuler SM, Boyle JT, Nixon TE, Pack AI, Cohen S. Simultaneous reflex inhibition of lower esophageal sphincter and crural diaphragm in cats. Am J Physiol Gastrointest Liver Physiol 1985; 249(5 Pt 1): G58691.
  • 24
    Martin CJ, Dodds WJ, Liem HH, Dantas RO, layman RD, Dent J. Diaphragmatic contribution to gastroesophageal competence and reflux in dogs. Am J Physiol 1992; 263(4 Pt 1): G5517.
  • 25
    Liu J, Pehlivanov N, Mittal RK. Baclofen blocks LES relaxation and crural diaphragm inhibition by esophageal and gastric distension in cats. Am J Physiol Gastrointest Liver Physiol 2002; 283: G127681.
  • 26
    Mittal RK, Rochester DF, McCallum RW. Sphinteric action of the diaphragm during a relaxed lower esophageal sphincter in humans. Am J Physiol 1989; 256(1 Pt 1): G13944.
  • 27
    Roberts TJ, Azizi E. Flexible mechanisms: the diverse roles of biological springs in vertebrate movement. J Exp Biol 2011; 214(Pt 3): 35361.
  • 28
    Pouderoux P, Lin S, Kahrilas PJ. Timing, propagation, coordination, and effect of esophageal shortening during peristalsis. Gastroenterology 1997; 112: 114754.
  • 29
    Wyman JB, Dent J, Heddle R, Dodds WJ, Toouli J, Downton J. Control of belching by the lower esophageal sphincter. Gut 1990; 31: 63946.
  • 30
    Sifrim D, Silny J, Holloway RH, Janssens JJ. Patterns of gas and liquid reflux during transient lower esophageal sphincter relaxation: a study using intra-luminal electrical impedance. Gut 1999; 44: 4754.
  • 31
    Mittal K, Stewart WR, Schirmer BD. Effect of a catheter in the pharynx on the frequency of transient lower esophageal sphincter relaxations. Gastroenterology 1992; 103: 123640.
  • 32
    Curci JA, Melman LM, Thompson RW, Soper NJ, Matthews BD. Elastic fiber depletion in the supporting ligaments of the gastroesophageal junction: a structural basis for the development of hiatal hernia. J Am Coll Sur 2008; 207: 1916.