Intestinal barrier function in health and gastrointestinal disease: Review Article


  • B. Greenwood-Van Meerveld

    1. Department of Physiology, Oklahoma Center for Neuroscience, VA Medical Center, University of Oklahoma Health Science Center
    Search for more papers by this author

Dear Editor,

We have read Claude Matuchansky’s letter and agree that he makes some very interesting points.

We acknowledge that intolerance to certain foods as well as food allergies can play a pivotal role in triggering symptoms in patients with of IBS. As stated in Dr. Matuchansky’s letter luminal nutrients can have profound effects on intestinal barrier function through multiple mechanisms including the stimulation of mechano- or chemoreceptors, activation of motor reflexes pathways, GI hormone release and immune-neuroimmune interactions. However, the scope of our article was somewhat limited by space available and we perceive that a separate, comprehensive article on the effects of food and dietary antigens (with reference to original data rather than reviews) would be a most welcome addition to this growing field.


No competing interests declared.