Comparison of calculations to estimate gastric emptying half-time of solids in humans

Authors

  • A. R. Zinsmeister,

    1. Department of Health Sciences Research, Division of Biomedical Statistics and Informatics, Mayo Clinic, College of Medicine, Rochester, MN, USA
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  • A. E. Bharucha,

    1. Clinical Enteric Neuroscience Translational and Epidemiological Research (CENTER), Mayo Clinic, College of Medicine, Rochester, MN, USA
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  • M. Camilleri

    1. Clinical Enteric Neuroscience Translational and Epidemiological Research (CENTER), Mayo Clinic, College of Medicine, Rochester, MN, USA
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  • Correction added after online publication 16 August 2012: ‘colonic compliance’ have been replaced by ‘gastric emptying’ in the running head.

Address for Correspondence
Michael Camilleri, Mayo Clinic, Charlton 8-110, 200 First St. S.W, Rochester, MN 55905, USA.
Tel: 507-266-2305; e-mail: camilleri.michael@mayo.edu

Abstract

Background  Measuring solid gastric emptying (GE) at 4 h is used to identify gastroparesis. GE half-time (GE T1/2) is useful to assess overall and early GE.

Aim  To examine the validity of hourly imaging as a measurement of GE T1/2 compared with estimates from more detailed imaging.

Methods  155 human subjects (99 female, 56 male) underwent scintigraphic GE of a solid–liquid meal. We calculated the GE T1/2 using linear interpolation based on a full set of abdominal images obtained over 4 h, and the GE T1/2 based on images at 1, 2, 3, and 4 h after the meal with interpolation of data.

Key Results  Differences in GE T1/2 values (entire set of scan times compared with just the hourly scans) were small [overall median (5th, 95th percentiles) = −0.2[−7.5, 4.6] min] with slightly greater differences in males compared with females. The agreement between the two methods was very high [concordance correlation coefficient (CCC) (95% CI) = 0.993 (0.990, 0.995)] and a Bland–Altman plot indicated the variation in the results between the two methods did not change appreciably across the range of GE studied (within ±10 min for all but four subjects). Calculated GE T1/2 values, omitting the 3-h data from the hourly measurements, were associated with similar high accuracy overall and for fast GE, but were less accurate with slow GE.

Conclusions & Inferences  Results of GE T1/2 solids, using hourly imaging over 4 h, are accurate in the range 75–235 min which reflects the typical range of GE of solids in health and disease.

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