Correction added after online publication 21 August 2012: Copyright line for the reuse of Figures 1 and 2 modified from “Permission obtained from Functional Somatic Syndromes, Eds: EA Mayer and C Bushnell” to “Adapted from229. This figure has been reproduced with permission of the International Association for the Study of Pain® (IASP®). The figure may not be reproduced for any other purpose without permission.”
Overlap between functional GI disorders and other functional syndromes: what are the underlying mechanisms?
Article first published online: 2 AUG 2012
© 2012 Blackwell Publishing Ltd
Neurogastroenterology & Motility
Volume 24, Issue 10, pages 895–913, October 2012
How to Cite
Kim, S. E. and Chang, L. (2012), Overlap between functional GI disorders and other functional syndromes: what are the underlying mechanisms?. Neurogastroenterology & Motility, 24: 895–913. doi: 10.1111/j.1365-2982.2012.01993.x
- Issue published online: 12 SEP 2012
- Article first published online: 2 AUG 2012
- Received: 8 April 2012 Accepted for publication: 10 July 2012
- chronic fatigue syndrome;
- functional dyspepsia;
- interstitial cystitis/painful bladder syndrome;
- irritable bowel syndrome;
- temporomandibular joint disorder
Abstract Background Irritable bowel syndrome and other gastrointestinal (GI) and non-GI disorders such as functional dyspepsia, fibromyalgia, temporomandibular joint disorder, interstitial cystitis/painful bladder syndrome, and chronic fatigue syndrome are known as functional pain syndromes. They commonly coexist within the same individual. The pathophysiologic mechanisms of these disorders are not well understood, but it has been hypothesized that they share a common pathogenesis.
Purpose The objective of this review is to discuss the proposed pathophysiologic mechanisms, which have been similarly studied in these conditions. These mechanisms include enhanced pain perception, altered regional brain activation, infectious etiologies, dysregulations in immune and neuroendocrine function, and genetic susceptibility. Studies suggest that these functional disorders are multifactorial, but factors which increase the vulnerability of developing these conditions are shared.