A prospective study of maternal carboxyhaemoglobin and pre-eclampsia risk
Version of Record online: 3 NOV 2009
© 2009 Blackwell Publishing Ltd.
Paediatric and Perinatal Epidemiology
Volume 24, Issue 1, pages 35–44, January 2010
How to Cite
Rudra, C. B., Williams, M. A., Schiff, M. A., Koenig, J. Q., Dills, R. and Yu, J. (2010), A prospective study of maternal carboxyhaemoglobin and pre-eclampsia risk. Paediatric and Perinatal Epidemiology, 24: 35–44. doi: 10.1111/j.1365-3016.2009.01076.x
- Issue online: 29 DEC 2009
- Version of Record online: 3 NOV 2009
- carbon monoxide;
- parity interaction;
- Omega Study
Rudra CB, Williams MA, Schiff MA, Koenig JQ, Dills R, Yu J. A prospective study of maternal carboxyhaemoglobin and pre-eclampsia risk. Paediatric and Perinatal Epidemiology 2010; 24: 35–44.
We aimed to measure the relationship between early-pregnancy maternal carboxyhaemoglobin and subsequent pre-eclampsia risk. A nested case–control analysis was conducted using data from a western Washington State cohort study (1996–2004). We measured maternal whole blood carboxyhaemoglobin in 128 women who developed pre-eclampsia and 419 normotensive controls (mean gestational age at blood draw, 14.8 weeks). After adjustment for confounders, high (≥1%) vs. low (<0.7%) carboxyhaemoglobin odds ratios [OR] and 95% confidence intervals [CI] were 4.09 [1.30, 12.9] in multiparous women, 0.53 [0.23, 1.26] in primiparae and 1.11 [0.55, 2.25] in the overall study population (parity interaction P = 0.01). The influence of parity on the association was unexpected. The association between high carboxyhaemoglobin and pre-eclampsia risk in multiparae implicates hypoxia at the fetal-maternal interface as a pathogenic mechanism. These results also suggest that the aetiology of the disease may differ according to parity.