Serum level of immunoglobulin E during pregnancy – does offspring sex matter?
Article first published online: 29 DEC 2009
© 2010 Blackwell Publishing Ltd.
Paediatric and Perinatal Epidemiology
Volume 24, Issue 1, pages 75–78, January 2010
How to Cite
Løken, M. O., Jeansson, S., Jenum, P. A. and Eskild, A. (2010), Serum level of immunoglobulin E during pregnancy – does offspring sex matter?. Paediatric and Perinatal Epidemiology, 24: 75–78. doi: 10.1111/j.1365-3016.2009.01092.x
- Issue published online: 29 DEC 2009
- Article first published online: 29 DEC 2009
- maternal IgE;
- fetal sex;
Løken MO, Jeansson S, Jenum PA, Eskild A. Serum level of immunoglobulin E during pregnancy – does offspring sex matter? Paediatric and Perinatal Epidemiology 2010; 24: 75–78.
We assessed maternal serum levels of total immunoglobulin E (IgE) in the first, second and third trimester and changes in total IgE levels from first to third trimester in relation to offspring sex. Within a cohort of 29 948 pregnant women, 392 women without a history of pre-eclampsia and with a liveborn child were randomly selected. Information on offspring sex was obtained through linkage to the Medical Birth Registry of Norway. Blood samples from each trimester were analysed for total IgE concentration. Differences in mean levels according to offspring sex were estimated and changes in total IgE levels from first to third trimester were assessed.
In all three trimesters there was a tendency of women carrying a male fetus to have a higher mean total IgE level, but significant statistical differences were not reached. The total IgE concentration decreased during pregnancy, but the decrement was less in women carrying a male fetus compared with those who carried a female fetus.