Association of maternal prenatal depressive symptoms with child cognition at age 3 years
Article first published online: 8 APR 2010
© 2010 Blackwell Publishing Ltd.
Paediatric and Perinatal Epidemiology
Volume 24, Issue 3, pages 232–240, May 2010
How to Cite
Tse, A. C., Rich-Edwards, J. W., Rifas-Shiman, S. L., Gillman, M. W. and Oken, E. (2010), Association of maternal prenatal depressive symptoms with child cognition at age 3 years. Paediatric and Perinatal Epidemiology, 24: 232–240. doi: 10.1111/j.1365-3016.2010.01113.x
- Issue published online: 8 APR 2010
- Article first published online: 8 APR 2010
- maternal prenatal depression;
- child cognition;
- child visual motor abilities
Tse AC, Rich-Edwards JW, Rifas-Shiman SL, Gillman MW, Oken E. Association of maternal prenatal depressive symptoms with child cognition at age 3 years. Paediatric and Perinatal Epidemiology 2010; 24: 232–240.
We examined the association of prenatal depressive symptoms at mid-pregnancy with child cognition at age 3 years in Project Viva, a pre-birth cohort study of 1030 mother–child pairs in eastern Massachusetts. We measured maternal depressive symptoms using the Edinburgh Postnatal Depression Scale (EPDS), a self-report measure validated for use during pregnancy. Measures of child cognition included the Peabody Picture Vocabulary Test (PPVT) and the Wide Range Achievement of Visual Motor Abilities (WRAVMA).
At mid-pregnancy, 81 mothers (7.9%) scored 13 or above on the EPDS, indicating probable depression. In the unadjusted model, children born to mothers with prenatal depressive symptoms had PPVT scores that were 3.8 points lower [95% confidence interval (CI) −7.1, −0.5]. With adjustment for sociodemographic variables, the association substantially attenuated [adjusted regression coefficient b for PPVT score = −0.7 (95% CI −3.6, 2.3)]. In both unadjusted and multivariable models, prenatal depressive symptoms were not associated with WRAVMA scores [adjusted b for total WRAVMA score = −0.5 (95% CI −3.0, 2.1)]. We found no evidence to suggest that maternal prenatal depression is independently associated with early child cognition.