Site of expression of immunity to Naegleria fowled in immunized mice

  1. Y. H. THONG1,
  2. R-F. CARTER2,
  3. A. FERRANTE1,*,
  4. B. ROWAN-KELLY1

Article first published online: 9 OCT 2007

DOI: 10.1111/j.1365-3024.1983.tb00724.x

Issue

Parasite Immunology

Parasite Immunology

Volume 5, Issue 1, pages 67–76, January 1983

Additional Information

How to Cite

THONG, Y. H., CARTER, R.-F., FERRANTE, A. and ROWAN-KELLY, B. (1983), Site of expression of immunity to Naegleria fowled in immunized mice. Parasite Immunology, 5: 67–76. doi: 10.1111/j.1365-3024.1983.tb00724.x

Author Information

  1. 1

    *Department of Paediatrics, University of Adelaide, Adelaide

  2. 2

    ‡Department of Histopathology, Adelaide Children's Hospital, North Adelaide, South Australia

* Department of Paediatrics, University of Adelaide, The Adelaide Children's Hospital, North Adelaide, S.A. 5006, Australia.

Publication History

  1. Issue published online: 9 OCT 2007
  2. Article first published online: 9 OCT 2007
  3. Accepted 6 May 1982

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Keywords:

  • Naegleria fowleri;
  • immunized mice;
  • protection;
  • histology;
  • nasal mucosa;
  • inflammation;
  • polymorphs;
  • epithelium shedding

Summary An experiment was performed which confirmed a previous finding that mice are protected against Naegleria fowleri infection by immunization with amoeba-free supernatant from amoeba cultures. Histological observations suggested that this protection is expressed mainly at the nasal mucosa and possibly results from the combined effects of polymorphonuclear leucocyte-mediated killing of the amoeba and mechanical elimination of the organisms by extensive shedding of necrotic epithelium.

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