These authors contributed equally to this work.
Helminth infection inhibits airway allergic reaction and dendritic cells are involved in the modulation process
Article first published online: 20 AUG 2009
© 2010 Blackwell Publishing Ltd
Volume 32, Issue 1, pages 57–66, January 2010
How to Cite
LIU, P., LI, J., YANG, X., SHEN, Y., ZHU, Y., WANG, S., WU, Z., LIU, X., AN, G., JI, W., GAO, W. and YANG, X. (2010), Helminth infection inhibits airway allergic reaction and dendritic cells are involved in the modulation process. Parasite Immunology, 32: 57–66. doi: 10.1111/j.1365-3024.2009.01161.x
- Issue published online: 9 DEC 2009
- Article first published online: 20 AUG 2009
- Received: 29 April 2009 Accepted for publication: 28 July 2009
- dendritic cells;
- hygiene hypothesis;
- Schistosoma japonicum
Several previous studies have demonstrated that some helminth infections can inhibit allergic reactions, but the examination on the effect of live Schistosoma japonicum (SJ) infection on allergic inflammation remains limited. The aim of this study was to examine the effect and mechanism of chronic SJ infection on airway allergic inflammation in a murine model. The data showed that chronic SJ infection suppressed airway eosinophilia, mucus production and antigen-specific IgE responses induced by ovalbumin (OVA) sensitization and challenge. Cytokine production analysis showed that chronic SJ infection reduced allergen-driven interleukin (IL)-4 and IL-5 production, but had no significant effect on IFN-γ production. More importantly, we found that the adoptive transfer of dendritic cells (DCs) from SJ-infected mice dramatically decreased airway allergic inflammation in the recipients, which was associated with significant decrease of IL-4/IL-5 production and increase of IL-10 production. The results suggest that SJ infection may inhibit the development of allergy and that DCs may be involved in the process of helminth infection-mediated modulation of allergic inflammation.