Present addresses: Department of Biological Sciences, Central Washington University, Ellensburg, WA 98926, USA,
CD4+ T cells mediate mucosal and systemic immune responses to experimental hookworm infection
Article first published online: 23 JAN 2010
© 2010 Blackwell Publishing Ltd
Volume 32, Issue 6, pages 406–413, June 2010
How to Cite
DONDJI, B., SUN, T., BUNGIRO, R. D., VERMEIRE, J. J., HARRISON, L. M., BIFULCO, C. and CAPPELLO, M. (2010), CD4+ T cells mediate mucosal and systemic immune responses to experimental hookworm infection. Parasite Immunology, 32: 406–413. doi: 10.1111/j.1365-3024.2010.01204.x
Disclosures: The authors do not have a commercial or other association that might pose a conflict of interest (e.g. pharmaceutical stock ownership, consultancy, advisory board membership, relevant patents).
- Issue published online: 10 MAY 2010
- Article first published online: 23 JAN 2010
- Received: 26 October 2009 Accepted for publication: 18 December 2009
- Ancylostoma ceylanicum;
- CD4+ T cells;
Hookworm infection is associated with anaemia and malnutrition in many resource-limited countries. Ancylostoma hookworms have previously been shown to modulate host cellular immune responses through multiple mechanisms, including reduced mitogen-mediated lymphocyte proliferation, impaired antigen presentation/processing, and relative reductions in CD4+ T cells in the spleen and mesenteric lymph nodes. Syrian hamsters were depleted of CD4+ for up to 9 days following intraperitoneal injection (200 μg) of a murine anti-mouse CD4 monoclonal IgG (clone GK1·5). CD4+ T-cell-depleted hamsters infected with the hookworm Ancylostoma ceylanicum exhibited a threefold higher mean intestinal worm burden and more severe anaemia than animals that received isotype control IgG. In addition, depletion of CD4+ T cells was associated with impaired cellular and humoral (serum and mucosal) immune responses to hookworm antigens. These data demonstrate an effector role for CD4+ T cells in hookworm immunity and disease pathogenesis. Ultimately, these studies may yield important insights into the relationship between intestinal nematode infections and diseases that are associated with CD4+ T-cell depletion, including HIV.