Present address: President’s Malaria Initiative (PMI), Centers for Disease Control and Prevention, Kigali, Rwanda.
Brief Definitive Report
Endogenous galectin-3 controls experimental malaria in a species-specific manner
Article first published online: 7 JUN 2012
© 2012 Blackwell Publishing Ltd
Volume 34, Issue 7, pages 383–387, July 2012
How to Cite
TOSCANO, M. A., TONGREN, J. E., De SOUZA, J. B., LIU, F.-T., RILEY, E. M. and RABINOVICH, G. A. (2012), Endogenous galectin-3 controls experimental malaria in a species-specific manner. Parasite Immunology, 34: 383–387. doi: 10.1111/j.1365-3024.2012.01366.x
- Issue published online: 7 JUN 2012
- Article first published online: 7 JUN 2012
- Accepted manuscript online: 6 APR 2012 11:06AM EST
- Received: 12 January 2012 Accepted for publication: 22 March 2012
- immunoglobulin G;
- Plasmodium spp.
Galectins are evolutionarily conserved glycan-binding proteins with pleiotropic roles in innate and adaptive immune responses. Galectin-3 has been implicated in several immunological processes as well as in pathogen recognition through specific binding to glycosylated receptors on the surface of host cells or microorganisms. In spite of considerable evidence supporting a role for galectin-3 in host–pathogen interactions, the relevance of this lectin in the regulation of the host defence mechanisms in vivo is poorly understood. In this study, we analysed the impact of galectin-3 deficiency during infection with three distinct species of rodent malaria parasites, Plasmodium yoelii 17XNL, Plasmodium berghei ANKA and Plasmodium chabaudi AS. We found that galectin-3 deficiency showed a marginal effect on the course of parasitaemia during P. chabaudi infection, but did not alter the course of parasitaemia during P. berghei infection. However, lack of galectin-3 significantly reduced P. yoelii parasitaemia. This reduced parasitaemia in Lgals3−/− mice was consistent with higher titres of anti-P. yoelii MSP119 IgG2b isotype antibodies when compared with their wild-type counterparts. Our results reflect the complexity and singularity of host–pathogen interactions, indicating a species-specific role of endogenous galectin-3 in the control of parasite infections and the modulation of antibody responses.