Neutrophil Chemotaxis Defect in IgA Deficiency Evaluated by Migration Agarose Method

Authors

  • R. D'AMELIO,

    1. Institute of Clinical Medicine III, Department of Infectious Diseases II, and Department of Pediatrics I, University of Rome, Rome, Italy
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  • S. LeMOLI,

    1. Institute of Clinical Medicine III, Department of Infectious Diseases II, and Department of Pediatrics I, University of Rome, Rome, Italy
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  • P. ROSSI,

    1. Institute of Clinical Medicine III, Department of Infectious Diseases II, and Department of Pediatrics I, University of Rome, Rome, Italy
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  • F. AIUTI

    Corresponding author
    1. Institute of Clinical Medicine III, Department of Infectious Diseases II, and Department of Pediatrics I, University of Rome, Rome, Italy
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F. Aiuti, Department of Infectious Diseases II, University of Rome 0016 Rome, Italy.

Abstract

The chemotactic and random mobility functions of twelve selectively IgA-deficient patients were evaluated by a method using agarose gel. A severe polymorphonuclear cellular chemotactic defect was found in ten out of twelve patients, but only five of them also showed a marked associated impairment of random locomotory function. Furthermore, in one subject, levamisole therapy resulted in a dramatic improvement of both chemotactic and random mobility functions. These results are discussed in the paper with respect to the possible pathogenetic implications.

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