Modulation of the Immune Response by Plasma Protease Inhibitors

I. Alpha2-Macroglobulin and Alpha1-Antitrypsin Inhibit Natural Killing and Antibody-dependent Cell-mediated Cytotoxicity

Authors

  • E. W. ADES,

    Corresponding author
    1. Department of Basic and Clinical Immunology and Microbiology, Medical University of South Carolina, Charleston, South Carolina, USA
      Dr E. W. Ades, Department of Immunology, Lilly Research Laboratories, 307 E. McCarty St, Indianapolis, IN 46285, USA
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  • A. HINSON,

    1. Department of Basic and Clinical Immunology and Microbiology, Medical University of South Carolina, Charleston, South Carolina, USA
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  • C. CHAPUIS-CELLIER,

    1. Department of Basic and Clinical Immunology and Microbiology, Medical University of South Carolina, Charleston, South Carolina, USA
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  • P. ARNAUD

    1. Department of Basic and Clinical Immunology and Microbiology, Medical University of South Carolina, Charleston, South Carolina, USA
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Dr E. W. Ades, Department of Immunology, Lilly Research Laboratories, 307 E. McCarty St, Indianapolis, IN 46285, USA

Abstract

The two major protease inhibitors in human serum, alpha1-antitrypsin (α1AT) and alpha2-macroglobulin (α2m), were analysed for their effects on antibody-dependent cell-mediated cytotoxocity (ADCC) and natural killing (NK). The results indicate that both α1AT and α2m decrease ADCC and NK in a dose-responsive pattern.

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