The Leucocyte L1 Protein: Identity with the Cystic Fibrosis Antigen and the Calcium-Binding MRP-8 and MRP-14 Macrophage Components

Authors

  • K. B. ANDERSSON,

    Corresponding author
    1. Department of Biochemistry, University of Oslo, Blood Bank and Department of Immunology, Ullevál Hospital, Laboratory for Immunohistochemistry and Immunopathology (LIIPAT), Institute of Pathology, University of Oslo, and Institute of Clinical Biochemistry, University of Oslo, The National Hospital, Rikshospitalet, Oslo, Norway
    Search for more papers by this author
  • K. SLETTEN,

    1. Department of Biochemistry, University of Oslo, Blood Bank and Department of Immunology, Ullevál Hospital, Laboratory for Immunohistochemistry and Immunopathology (LIIPAT), Institute of Pathology, University of Oslo, and Institute of Clinical Biochemistry, University of Oslo, The National Hospital, Rikshospitalet, Oslo, Norway
    Search for more papers by this author
  • H. B. BERNTZEN,

    1. Department of Biochemistry, University of Oslo, Blood Bank and Department of Immunology, Ullevál Hospital, Laboratory for Immunohistochemistry and Immunopathology (LIIPAT), Institute of Pathology, University of Oslo, and Institute of Clinical Biochemistry, University of Oslo, The National Hospital, Rikshospitalet, Oslo, Norway
    Search for more papers by this author
  • I. DALE,

    1. Department of Biochemistry, University of Oslo, Blood Bank and Department of Immunology, Ullevál Hospital, Laboratory for Immunohistochemistry and Immunopathology (LIIPAT), Institute of Pathology, University of Oslo, and Institute of Clinical Biochemistry, University of Oslo, The National Hospital, Rikshospitalet, Oslo, Norway
    Search for more papers by this author
  • P. BRANDTZAEG,

    1. Department of Biochemistry, University of Oslo, Blood Bank and Department of Immunology, Ullevál Hospital, Laboratory for Immunohistochemistry and Immunopathology (LIIPAT), Institute of Pathology, University of Oslo, and Institute of Clinical Biochemistry, University of Oslo, The National Hospital, Rikshospitalet, Oslo, Norway
    Search for more papers by this author
  • E. JELLUM,

    1. Department of Biochemistry, University of Oslo, Blood Bank and Department of Immunology, Ullevál Hospital, Laboratory for Immunohistochemistry and Immunopathology (LIIPAT), Institute of Pathology, University of Oslo, and Institute of Clinical Biochemistry, University of Oslo, The National Hospital, Rikshospitalet, Oslo, Norway
    Search for more papers by this author
  • M. K. FAGERHOL

    1. Department of Biochemistry, University of Oslo, Blood Bank and Department of Immunology, Ullevál Hospital, Laboratory for Immunohistochemistry and Immunopathology (LIIPAT), Institute of Pathology, University of Oslo, and Institute of Clinical Biochemistry, University of Oslo, The National Hospital, Rikshospitalet, Oslo, Norway
    Search for more papers by this author

Kristin Brevik Andersson, The Norwegian Radium Hospital, Institute for Cancer Research, Laboratory for Immunology, Montebello, 0310 Oslo, Norway

Abstract

The partial amino acid sequence of L1 protein light and heavy chains reveals an overall structure identical to the two macrophage proteins, MRP-8 and MRP-14, deduced from the sequence of the cDNA encoding the polypeptides. The light chain of L1 protein (L1-L) was shown to contain two modified amino acid residues.

Ancillary