The Major Histocompatibility Complex (MHC) of the Secondary Transplant Tissue Donor Influences the Cross-Reactivity of Alloreactive Memory Cells

  1. F. Wang1,†,
  2. J. Chen2,†,
  3. W. Shao1,
  4. X. Kang1,
  5. S. Xu1,
  6. J. Xia1,
  7. H. Dai1,
  8. Y. Peng1,
  9. H. Thorlacius3,
  10. J. Xing4,
  11. Z. Qi1

Article first published online: 8 FEB 2011

DOI: 10.1111/j.1365-3083.2010.02493.x

Issue

Scandinavian Journal of Immunology

Scandinavian Journal of Immunology

Volume 73, Issue 3, pages 190–197, March 2011

Additional Information

How to Cite

Wang, F., Chen, J., Shao, W., Kang, X., Xu, S., Xia, J., Dai, H., Peng, Y., Thorlacius, H., Xing, J. and Qi, Z. (2011), The Major Histocompatibility Complex (MHC) of the Secondary Transplant Tissue Donor Influences the Cross-Reactivity of Alloreactive Memory Cells. Scandinavian Journal of Immunology, 73: 190–197. doi: 10.1111/j.1365-3083.2010.02493.x

Author Information

  1. 1

    Organ Transplantation Institute, Xiamen University, Xiamen, Fujian Province, China

  2. 2

    Basic Medical Department of Medical College, Xiamen University, Xiamen, Fujian Province, China

  3. 3

    Malmö Hospital of Lund University, Malmö, Sweden

  4. 4

    Department of Urology, the First Affiliated Hospital of Xiamen University, Xiamen, China

  1. †

    Both authors contributed equally to the study and share first authorship.

*Z. Qi, Organ Transplantation Institute, Xiamen University, Xiamen, Fujian Province 361005, China. E-mail: oti@xmu.edu.cn
J. Xing, Department of Urology, the First Affiliated Hospital of Xiamen University, Xiamen, Fujian Province 361005, China. E-mail: xmcua2007@sina.com

Publication History

  1. Issue published online: 8 FEB 2011
  2. Article first published online: 8 FEB 2011
  3. Accepted manuscript online: 20 NOV 2010 09:45AM EST
  4. Received 13 October 2010; Accepted 10 November 2010

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article with Supporting Information (HTML) Get PDF (839K)

Abstract

Memory cells are currently thought to be a major barrier to tolerance induction in transplantation. However, whether alloreactive memory cells resulting from a primary transplant have cross-reactivity in a second transplant is unclear. Here, we used skin transplantation from BALB/c mice donors to presensitize C57BL/6 (B6) mice. One month later, several strains of mice (including BALB/c, DBA/2, NOD, C3H and B6 mice) were chosen as donors to construct a memory model of heterotopic cardiac transplantation. The higher degree of major histocompatibility complex (MHC) mismatch to sensitizing MHC resulted in longer median survival times (MSTs, BALB/c 3.63 days versus C3H 6.08 days). After 3.5 days of cardiac transplantation, compared with the BALB/c and DBA/2 groups, in the groups of NOD and C3H, the infiltration of inflammatory cells in the grafts, the proportion and proliferation of memory cells in spleens and the function of allogeneic antibodies decreased significantly. The varying degrees of MHC mismatch between the primary and secondary donors influenced the intensity of alloreactive memory cell function, the higher degree of MHC mismatch resulted in better tolerance during secondary transplantation, and these may be related to the changed activation, proliferation and function of the alloreactive memory cells.

View Full Article with Supporting Information (HTML) Get PDF (839K)