Role of plant CBP/p300-like genes in the regulation of flowering time

Authors

  • Soon-Ki Han,

    1. Environmental Biotechnology National Core Research Center, Gyeongsang National University, Jinju 660-701,
    2. Global Research Laboratory for Flowering, Seoul National University, Seoul 151-742, and
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  • Ju-Dong Song,

    1. Global Research Laboratory for Flowering, Seoul National University, Seoul 151-742, and
    2. Department of Biological Sciences, Seoul National University, Seoul 151-742, Korea
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  • Yoo-Sun Noh,

    Corresponding author
    1. Global Research Laboratory for Flowering, Seoul National University, Seoul 151-742, and
      (fax +82 2 871 6673; e-mail bnoh2003@yahoo.co.kr or ysnoh@snu.ac.kr).
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  • Bosl Noh

    Corresponding author
    1. Environmental Biotechnology National Core Research Center, Gyeongsang National University, Jinju 660-701,
    2. Global Research Laboratory for Flowering, Seoul National University, Seoul 151-742, and
      (fax +82 2 871 6673; e-mail bnoh2003@yahoo.co.kr or ysnoh@snu.ac.kr).
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(fax +82 2 871 6673; e-mail bnoh2003@yahoo.co.kr or ysnoh@snu.ac.kr).

Summary

CREB-binding protein (CBP) and its homolog p300 possess histone acetyltransferase activity and function as key transcriptional co-activators in the regulation of gene expression that controls differentiation and development in animals. However, the role of CBP/p300-like genes in plants has not yet been elucidated. Here, we show that Arabidopsis CBP/p300-like genes promote flowering by affecting the expression of a major floral repressor FLOWERING LOCUS C (FLC). Although animal CBP and p300 generally function as co-activators, Arabidopsis CBP/p300-like proteins are required for the negative regulation of FLC. This CBP/p300-mediated FLC repression may involve reversible protein acetylation independent of histone modification within FLC chromatin.

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