Present address: Chris C. N. van Schie, University of California San Diego, 9500 Gilman Drive #380, La Jolla, CA 92093-0380, USA.
Geranyl diphosphate synthase is required for biosynthesis of gibberellins
Article first published online: 18 SEP 2007
The Plant Journal
Volume 52, Issue 4, pages 752–762, November 2007
How to Cite
Van Schie, C. C. N., Ament, K., Schmidt, A., Lange, T., Haring, M. A. and Schuurink, R. C. (2007), Geranyl diphosphate synthase is required for biosynthesis of gibberellins. The Plant Journal, 52: 752–762. doi: 10.1111/j.1365-313X.2007.03273.x
- Issue published online: 18 SEP 2007
- Article first published online: 18 SEP 2007
- Received 9 April 2007; revised 16 July 2007; accepted 25 July 2007.
- geranyl diphosphate synthase;
- virus-induced gene silencing
Geranyl diphosphate synthase (GPS) is generally considered to be responsible for the biosynthesis of monoterpene precursors only. However, reduction of LeGPS expression in tomato (Lycopersicon esculentum) by virus-induced gene silencing resulted in severely dwarfed plants. Further analysis of these dwarfed plants revealed a decreased gibberellin content, whereas carotenoid and chlorophyll levels were unaltered. Accordingly, the phenotype could be rescued by application of gibberellic acid. The dwarfed phenotype was also obtained in Arabidopsis thaliana plants transformed with RNAi constructs of AtGPS. These results link geranyl diphosphate (GPP) to the gibberellin biosynthesis pathway. They also demand a re-evaluation of the role of GPS in precursor synthesis for other di-, tri-, tetra- and/or polyterpenes and their derivatives.