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Figure S1. The biosynthetic pathway of ubiquinone in eukaryotes. The eubacterial and yeast enzymes corresponding to each individual reaction belong to the Ubi and Coq series, respectively. Asteriks indicate the Arabidopsis orthologs that are detected in the functional network of At2g34630 shown in Figure 2. Dashed arrows and question marks indicate hypothetical reactions. AACT, acetoacetyl-CoA thiolase; DPMDC, 5-diphosphomevalonate decarboxylase; HMGS, 3-hydroxy-3-methylglutaryl-CoA synthase; HMGR, 3-hydroxy-3-methylglutaryl-CoA reductase; IspB, E.  coli octaprenyl diphosphate synthase; MK, mevalonate kinase; PMK, 5-phosphomevalonate kinase.

Table S1. Spearman’s Rho (rs) rank correlation values.

Table S2. Organisms of origin and accession numbers of trans-long chain prenyl diphosphate synthases used for phylogenetic analysis.

Video Clip S1. Time lapse imaging of At2g34630-GFP fused construct transiently expressed in tobacco leaves.

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