SUMMARY. Fresh frozen plasma should only be used to treat bleeding episodes or prepare patients for surgery in certain defined situations.
Definite indications for the use of FFP
- 1 Replacement of single coagulation factor deficiencies, where a specific or combined factor concentrate is unavailable.
- 2 Immediate reversal of warfarin effect.
- 3 Acute disseminated intravascular coagulation (DIC).
- 4 Thrombotic thrombocytopenic purpura (TTP).
Conditional uses: FFP only indicated in the presence of bleeding and disturbed coagulation
- 1 Massive transfusion.
- 2 Liver disease.
- 3 Cardiopulmonary bypass surgery.
- 4 Special paediatric indications.
No justification for the use of FFP
- 1 Hypovolaemia.
- 2 Plasma exchange procedures.
- 3 ‘Formula’ replacement.
- 4 Nutritional support.
- 5 Treatment of immunodeficiency states.