Guidelines for the use of fresh frozen plasma


British Society for Haematology, 2 Carlton House Terrace, London SW1Y 5AF, U.K.


SUMMARY. Fresh frozen plasma should only be used to treat bleeding episodes or prepare patients for surgery in certain defined situations.

Definite indications for the use of FFP

  • 1 Replacement of single coagulation factor deficiencies, where a specific or combined factor concentrate is unavailable.
  • 2 Immediate reversal of warfarin effect.
  • 3 Acute disseminated intravascular coagulation (DIC).
  • 4 Thrombotic thrombocytopenic purpura (TTP).

Conditional uses: FFP only indicated in the presence of bleeding and disturbed coagulation

  • 1 Massive transfusion.
  • 2 Liver disease.
  • 3 Cardiopulmonary bypass surgery.
  • 4 Special paediatric indications.

No justification for the use of FFP

  • 1 Hypovolaemia.
  • 2 Plasma exchange procedures.
  • 3 ‘Formula’ replacement.
  • 4 Nutritional support.
  • 5 Treatment of immunodeficiency states.