SEARCH

SEARCH BY CITATION

Keywords:

  • GPIa/IIa antibody;
  • HPA-1a antibody;
  • platelets;
  • post-transfusion purpura (PTP)

summary.  Post-transfusion purpura is a rare bleeding disorder characterized by severe and sudden thrombocytopenia within 3–12 days after blood transfusion. Typically, preformed antibodies directed against human platelet antigens, especially HPA-1a, are associated with the clinical symptoms. A 46-year-old female presenting to the hospital with acute progressive kidney insufficiency and anaemia received two units of packed red blood cells (RBC) within 2 days. On day 7, platelet count felt from 414 to 189 × 109 L−1 and 1 day later dropped to 4 × 109 L−1. Four platelet concentrates were applied without success. After serological confirmation of an HPA-1a antibody, the patient was treated with intravenous gamma immunoglobulin (ivIgG), and the platelet count increased to normal values on day 17. In addition to the persisting HPA-1a alloantibody, an antibody reactive with GPIa/IIa of HPA-5a- and HPA-5b-positive platelets was detected during the acute phase of thrombocytopenia. After complete remission, the patient was transfused with four units of packed RBC from HPA-1a-negative donors, and platelet counts remained normal.