Risk factors for chronic hepatitis B virus infection among blood donors in Bangalore, India
Article first published online: 18 AUG 2010
© 2010 The Authors. Transfusion Medicine © 2010 British Blood Transfusion Society
Volume 20, Issue 6, pages 414–420, December 2010
How to Cite
Jagannathan, L., Chaturvedi, M., Mudaliar, S., Kamaladoss, T., Rice, M. and Murphy, E. L. (2010), Risk factors for chronic hepatitis B virus infection among blood donors in Bangalore, India. Transfusion Medicine, 20: 414–420. doi: 10.1111/j.1365-3148.2010.01032.x
- Issue published online: 19 OCT 2010
- Article first published online: 18 AUG 2010
- Recieved 10 March 2010; accepted for publication 07 July 2010
- blood donors;
- hepatitis B virus
Objectives and Aim: We performed a study of hepatitis B virus (HBV) risk factors among blood donors in Bangalore, India.
Background: HBV infection is prevalent in India and poses a potential risk of transmission by blood transfusion, but studies of risk factors for hepatitis B surface antigen (HBsAg) carriage among Indian blood donors are lacking.
Methods/Materials: Using a case-cohort design, we enrolled 71 cases with repeatedly reactive HBsAg results and a cohort of 212 contemporaneous blood donors with unknown HBsAg status. Questionnaire data were analysed using multivariable logistic regression.
Results: In our multivariate analysis controlling for age, HBsAg positivity was associated with repeat donor status (OR = 0·34, 95% CI 0·17–0·71 vs first-time donor status), residence outside Bangalore and Hosur (rural areas) (OR = 15·66, 95% CI 3·60–68·07vs Bangalore residence), having been a customer at a local barber shop (OR = 4·07, 95% CI 2·06–8·03), close contact with a person who had jaundice (OR = 13·64, 95% CI 3·71–50·24) and cigarette smoking (OR = 3·25, 95% CI 1·39–7·60).
Conclusion: In addition to recognised demographic risk factors, associations with patronage of local barbers and contact with jaundiced individuals suggest behavioural risk factors that could be adopted as exclusionary criteria for blood donation in India.