Feature Page


Dihydroartemisinin-piperaquine is a new and promising antimalarial combination, which is now recommended by the European-Medicine-Agency in the EU and, globally, by WHO for the first-line treatment of uncomplicated malaria. 1466–1473


Zinc supplementation seems to be beneficial in adult patients with HIV-infection in some aspects. More research is needed in children and pregnant women. The influence of zinc dose, duration and usage of antiretroviral medicine also require further investigation. 1474–1482

Burial surveillance plus verbal autopsy demonstrated a significant reduction in HIV- deaths during the provision of free ART in Ethiopia. Burial surveillance is useful in settings to track large-scale population-level interventions. 1483–1489

In KwaZulu Natal HIV testing of children is infrequent despite high testing coverage among caregivers. This is worrying as children are at high risk of morbidity and mortality from untreated childhood HIV infection. 1490–1494

Cases of immunological failure should be confirmed with viral load testing before switching to second-line ART to optimize the use of resources in developing countries. 1495–1500


In Indonesia accessibility of care providers is the main determinant of patient delay in seeking treatment for TB, but the role of psychosocial factors cannot be excluded. Efforts to ensure equitable access to DOTS should be prioritized. 1501–1510

In Shandong, PRC, active case finding through symptom screening and sputum microscopy of close contacts yielded 0.7% of smear positive TB cases. Clear operational guidelines and adequate training were key factors. 1511–1517


Cooking with an iron ingot is a cheap and sustainable means of improving iron intake for those with iron-deficient diets. 1518–1524

Ultrasound Use

Ultrasound is a highly valuable diagnostic tool in low and middle income countries. It is most com-monly used for obstetrical conditions and alters clinical management in more than 30% of cases. 1525–1535


Anal cleansing is a necessary human activity. But due to social taboos, there are few articles on the topic, and school health plans overlook it too. We need to determine if and how current practices could harm child health in order to inform policy. 1536–1540


Single dose rifampicin, ofloxacin, and minocycline (ROM) therapy is less effective than multidrug therapy in paucibacillary leprosy patients. Data on the efficacy of multidose ROM therapy in multibacillary leprosy are insufficient to permit a valid conclusion. 1541–1551


Household ITN ownership and use remain below the current Roll Back Malaria targets of universal coverage in Ethiopia. A new strategy is urgently needed to scale-up use of ITNs. 1552–1561