Pemphigus foliaceus-like drug reaction in a 3-month-old crossbreed dog treated for juvenile cellulitis

Authors

  • Christa Horvath,

    1. Clinic of Internal Medicine and Infectious Diseases, University of Veterinary Medicine Vienna, Veterinärplatz 1, A-1210 Vienna, Austria
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  • Ariane Neuber,

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    • *

      Present address: Derm4Pets, c/o Great Western Referrals, Unit 10, Berkshire House, County Park Business Park, Shrivenham Road, Swindon SN1 2NR, UK

  • Barbara Litschauer

    1. Clinic of Internal Medicine and Infectious Diseases, University of Veterinary Medicine Vienna, Veterinärplatz 1, A-1210 Vienna, Austria
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Christa Horvath, Easter Bush Veterinary Centre, Hospital for Small Animals, University of Edinburgh, Roslin, Midlothian EH25 9RG, Scotland. E-mail: chorvath@staffmail.ed.ac.uk

Abstract

Two weeks after administration of routine vaccinations, a 3-month-old, male crossbreed dog developed cutaneous lesions that were clinically and histopathologically consistent with a diagnosis of juvenile cellulitis. The patient was treated with systemic antibacterial, antibacterial ophthalmic ointment and nonsteroidal anti-inflammatory drugs. Within 1 week, new skin lesions that were clinically, histopathologically and immunohistochemically consistent with pemphigus foliaceus developed. The latter completely resolved following drug withdrawal, suggesting a pemphigus foliaceus-like drug reaction. However, the initial lesions persisted and required glucocorticoid therapy to effect resolution. To the authors’ knowledge, this is the first reported case of a puppy developing juvenile cellulitis followed by a pemphigus foliaceus-like reaction shortly thereafter, in response to drug therapy.

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