Conflicts of Interest From 1997 to 2008, Thierry Olivry has participated in NC State University-approved consulting activities for Novartis Animal Health Switzerland (distributors of ciclosporin, which is reviewed herein), Schering-Plough Animal Health USA, Sogeval USA and Janssen Animal Health, Belgium. From 1997 to 2008, he has obtained research funding from Corixa USA, Heska USA, Nosan Japan, Novartis Animal Health Global, Oligos USA, Searle (distributors of misoprostol discussed herein) USA, Schering-Plough Animal Health USA, Virbac France (distributors of Genesis triamcinolone spray mentioned herein) and Nippon Zenyaku (Zenoaq) Japan. Ralf Mueller has consulted for Novartis Animal Health Switzerland (distributors of ciclosporin reviewed herein) and Royal Canin France. He has obtained research funding from Bayer Animal Health Germany, Boehringer Ingelheim Denmark, Laboratoire de Dermo-Cosmétique Animale (LDCA) France, Pfizer Animal Health Germany, Procter & Gamble USA, TEVA Animal Health (previously DVM-IVX) USA and Virbac France (European distributors of Histacalmine hydroxyzine–chlorpheniramine combination, and whose US subsidiary distributes Genesis triamcinolone spray; both are reviewed in this paper). Chris Chesney consulted for Schering-Plough and Pfizer Animal Health UK. Neil McEwan has obtained research funding from Leo Denmark, Virbac France and Schering-Plough Animal Health UK, and he participated in a trial funded by Phytopharm UK. Prior to 2004, Aiden Foster acted as consultant to Merial Animal Health UK, Leo Animal Health UK and Pfizer Animal Health UK; for Novartis Animal Health Inc. and Phytopharm plc who manufacture ciclosporin and PO7P respectively. Before 2004, he obtained research funding from Merial, Novartis and the Heska Corporation. Hywel Williams does not have any conflicts of interest.
Interventions for atopic dermatitis in dogs: a systematic review of randomized controlled trials
Article first published online: 28 JAN 2010
© 2010 The Authors. Journal compilation © 2010 ESVD and ACVD
Volume 21, Issue 1, pages 4–22, February 2010
How to Cite
Olivry, T., Foster, A. P., Mueller, R. S., McEwan, N. A., Chesney, C. and Williams, H. C. (2010), Interventions for atopic dermatitis in dogs: a systematic review of randomized controlled trials. Veterinary Dermatology, 21: 4–22. doi: 10.1111/j.1365-3164.2009.00784.x
Funding None declared.
- Issue published online: 28 JAN 2010
- Article first published online: 28 JAN 2010
- Accepted 7 May 2009
- 10Summarizing the evidence. In: GuyattG, RennieD, eds. Users’ Guides to the Medical Literature – Essentials of Evidence-Based Medicine. Chicago, IL: AMA Press, 2002: 241–69., , et al.
- 12Réévaluation des critères de diagnostic de la dermite atopique [Reevaluation of diagnostic criteria of atopic dermatitis]. Revue De Médecine Vétérinaire 1998; 149: 1057–64., , et al.
- 15A double-blind trial evaluating homeopathic drops in the treatment of atopy in 20 dogs (abstract). In: KwochkaKW, WillemseT, Von TscharnerC, eds. Advances in Veterinary Dermatology, Vol. 3. Oxford, UK: Butterworth-Heinemann, 1998: 508–9..
- 23Traitement de la dermite atopique canine par un copolymere d’acides gras: Une etude clinique comparative en double aveugle [Treatment of canine atopic dermatitis by a fatty acid copolymer: comparative double blind study]. Pratique Médicale et Chirurgicale de l’Animal de Compagnie 2001; 36: 401–8., .
- 25Usefulness of one hypoallergenic diet in the management of atopic dermatitis in dogs (abstract). Veterinary Dermatology 2002; 14: 261..
- 26Maintenance treatment of canine atopic dermatitis with cyclosporine: Decreasing dosages or increasing intervals? (abstract). Veterinary Dermatology 2003; 14: 220., , et al.
- 33A randomized, double-blind, placebo-controlled trial to investigate the efficacy and safety of a Chinese herbal product (P07P) for the treatment of canine atopic dermatitis. Veterinary Dermatology 2001; 12: 265–74., , et al.
- 35Further investigations on the use of nonsteroidal and steroidal antiinflammatory agents in the management of canine pruritus. Journal of the American Animal Hospital Association 1991; 27: 44–8., , .
- 38Anti-allergic shampoo and oral essential fatty acid combination therapy to relieve signs of canine atopic dermatitis: a blinded, prednisolone-controlled trial (abstract). Veterinary Dermatology 2005; 14: 355., , et al.
- 39Investigation on the clinical efficacy and safety of 0.1% tacrolimus ointment (protopic) in canine atopic dermatitis: a randomized, double-blinded, placebo-controlled, cross-over study. Veterinary Dermatology 2004; 15: 294–303., , et al.
- 44Nonsteroidal antipruritic drugs in dogs and cats: an update. Bulletin of the Canadian Academy of Veterinary Dermatology 1996; 3–7..
- 48Conventional and rush allergen-specific immunotherapy in the treatment of canine atopic dermatitis. In: HillierA, FosterAP, KwochkaKW, eds. Advances in Veterinary Dermatology, Vol. 5. Oxford, UK: Blackwell Publishing, 2005: 60–9., , et al.
- 52Double blind, placebo-controlled, crossover study of evening primrose oil in the treatment of canine atopy. Veterinary Record 1992; 13: 97–9., .
- 53Comparison of the clinical efficacy of two commercial fatty acid supplements (efavet and DVM DermCaps), evening primrose oil, and cold water marine fish oil in the management of allergic pruritus in dogs: a double-blinded study. Cornell Veterinarian 1992; 82: 319–29., , et al.
- 57Efficacia dell’olio di semi di ribes nero nella dermatite atoica del cane: Uno studio in doppio cieco controllato da placebo [Efficacy of blackcurrant seed oil in canine atopic dermatitis: a double blind placebo controlled study]. Veterinaria Cremona 2002; 16: 55–60., .
- 60Efficacy of an essential fatty acid supplement to reduce clinical signs of atopic dermatitis in dogs and to change serum fatty acid levels: a double-blinded placebo-controlled cross-over study (abstract). Veterinary Dermatology 2005; 16: 356., , et al.
- 61A randomized, controlled, double-blinded, multicentre study on the efficacy of a diet rich in fish oil and borage oil in the control of canine atopic dermatitis. In: HillierA, FosterAP, KwochkaKW, eds. Advances in Veterinary Dermatology, Vol. 5. Oxford, UK: Blackwell Publishing, 2005: 173–87., , et al.